Titre du document / Document title
Coriander anaphylaxis in A spice grinder with undetected occupational allergy
Auteur(s) / Author(s)
EBO D. G. (1) ;
BRIDTS C. H. (1) ;
MERTENS M. H. (1) ;
STEVENS W. J. (1) ;
Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)
(1) Dept Immunology - Allergology - Rheumatology, University Antwerp, BELGIQUE
Résumé / Abstract
Background: Anaphylaxis after ingestion of spices as a result from occupational sensitization remains anecdotal. We describe a patient, working in a spice factory, with anaphylaxis from coriander in a meal. He also demonstrated urticaria, angio-edema, rhinoconjunctivitis and bronchospasm during handling coriander and fenugreek. Objective: To determine the mechanism of the anaphylactic reaction and to evaluate cross-reactivity between both botanically unrelated spices. Methods: Investigations comprised quantification of total and specific IgE by Immuno-CAP FEIA, skin testing, basophil activation experiments by flow-assisted determination of CD63 expression in the patient and 3 healthy controls. Immuno-CAP inhibition experiments were applied to investigate cross-reactivity. Results: Specific IgE, skin tests and basophil activation tests were clearly positive in the patient, whereas they remained negative in controls. No cross-reactivity between fenugreek and coriander was demonstrable by inhibition experiments. Conclusions: The clinical manifestations in temporal relationship to ingestion of coriander and handling of coriander and/or fenugreek, the positive specific IgE results, skin tests and basophil activation assays support the diagnosis of allergy to both spices. History suggests sensitization by occupational exposure.
Revue / Journal Title
Acta clinica belgica
ISSN
0001-5512
Source / Source
2006, vol. 61, n
o3, pp. 152-156 [5 page(s) (article)] (46 ref.)
Langue / Language
Anglais
Editeur / Publisher
Acta Clinica Belgica, Gent, BELGIQUE
(1946-1997)
(Revue)
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Localisation / Location
INIST-CNRS, Cote INIST : 8043, 35400015308027.0070
Nº notice refdoc (ud4) : 17926832
