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Titre du document / Document title

Coriander anaphylaxis in A spice grinder with undetected occupational allergy

Auteur(s) / Author(s)

EBO D. G. (1) ; BRIDTS C. H. (1) ; MERTENS M. H. (1) ; STEVENS W. J. (1) ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

(1) Dept Immunology - Allergology - Rheumatology, University Antwerp, BELGIQUE

Résumé / Abstract

Background: Anaphylaxis after ingestion of spices as a result from occupational sensitization remains anecdotal. We describe a patient, working in a spice factory, with anaphylaxis from coriander in a meal. He also demonstrated urticaria, angio-edema, rhinoconjunctivitis and bronchospasm during handling coriander and fenugreek. Objective: To determine the mechanism of the anaphylactic reaction and to evaluate cross-reactivity between both botanically unrelated spices. Methods: Investigations comprised quantification of total and specific IgE by Immuno-CAP FEIA, skin testing, basophil activation experiments by flow-assisted determination of CD63 expression in the patient and 3 healthy controls. Immuno-CAP inhibition experiments were applied to investigate cross-reactivity. Results: Specific IgE, skin tests and basophil activation tests were clearly positive in the patient, whereas they remained negative in controls. No cross-reactivity between fenugreek and coriander was demonstrable by inhibition experiments. Conclusions: The clinical manifestations in temporal relationship to ingestion of coriander and handling of coriander and/or fenugreek, the positive specific IgE results, skin tests and basophil activation assays support the diagnosis of allergy to both spices. History suggests sensitization by occupational exposure.

Revue / Journal Title

Acta clinica belgica    ISSN  0001-5512 

Source / Source

2006, vol. 61, no3, pp. 152-156 [5 page(s) (article)] (46 ref.)

Langue / Language

Anglais

Editeur / Publisher

Acta Clinica Belgica, Gent, BELGIQUE  (1946-1997) (Revue)

Mots-clés anglais / English Keywords

Immunopathology

;

Leguminosae

;

Spermatophyta

;

Angiospermae

;

Dicotyledones

;

Umbelliferae

;

Flow cytometry

;

Fenugreek

;

Trigonella foenum graecum

;

Occupational medicine

;

Occupational exposure

;

Spice

;

Anaphylaxis

;

Coriander

;

Coriandrum sativum

;

Allergy

;

Mots-clés français / French Keywords

Immunopathologie

;

Leguminosae

;

Spermatophyta

;

Angiospermae

;

Dicotyledones

;

Umbelliferae

;

Antigène CD63

;

Cytométrie flux

;

Trigonelle

;

Trigonella foenum graecum

;

Médecine du travail

;

Exposition professionnelle

;

Epice

;

Anaphylaxie

;

Coriandre

;

Coriandrum sativum

;

Allergie

;

Mots-clés espagnols / Spanish Keywords

Inmunopatología

;

Leguminosae

;

Spermatophyta

;

Angiospermae

;

Dicotyledones

;

Umbelliferae

;

Citometría flujo

;

Alholva

;

Trigonella foenum graecum

;

Medicina ocupacional

;

Exposición profesional

;

Especia

;

Anafilaxia

;

Cilantro

;

Coriandrum sativum

;

Alergia

;

Mots-clés d'auteur / Author Keywords

anaphylaxis

;

CD63

;

coriander

;

fenugreek

;

flow cytometry

;

occupational allergy

;

Localisation / Location

INIST-CNRS, Cote INIST : 8043, 35400015308027.0070

Nº notice refdoc (ud4) : 17926832



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