RefDoc
Haut

Faire une nouvelle recherche
Make a new search
Lancer la recherche


Titre du document / Document title

HLA-Class II (DRB & DQB1) in Thai sudden unexplained death syndrome (Thai SUDS) families (Lai-Tai families)

Auteur(s) / Author(s)

HIMMUNNGAN Pensiri (1) ; SANGWATANAROJ Somkiat (2) ; PETMITR Songsak (3) ; VIROONUDOMPHOL Duangkamol (3) ; SIRIYONG Pakorn (4) ; PATMASIRIWAT Pimpicha (5) ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

(1) Institute of Pathology, Department of Medical Services, Bangkok, THAILANDE
(2) Cardiovascular Division, Department of Medicine, Faculty of Medicine Chulalongkorn University, Bangkok, THAILANDE
(3) Faculty of Tropical Medicine, Mahidol University, Bangkok, THAILANDE
(4) Department of Medical Services, Ministry of Public Health, Nonthaburi, THAILANDE
(5) Faculty of Medical Technology, Mahidol University, Bangkok, THAILANDE

Résumé / Abstract

Thai Sudden Unexplained Death Syndrome (Thai SUDS), or Lai-Tai, is a major health problem among rural residents of northeastern Thailand. The cause has been identified as a genetic disease. SUDS, a disorder found in Southeast Asia, is characterized by an abnormal electrocardiogram with ST-segment elevation in leads V1 -V3, identical to that seen in Brugada Syndrome (Brugada Sign, BS) and sudden death due to ventricular fibrillation and cardiac arrest (represents an arrhythmogenic marker that identifies high-risk for SUDS). SUDS victims have a sleeping disorder (narcolepsy). The HLA-DR locus is tightly associated with narcoleptic Japanese patients and HLA-DR2, DQ haplotypes were also found in Oriental narcoleptic patients. These circumstances prompted us to study the association between the disease and HLA Class II by HLA DNA typing using a PCR-SSO method, with five Thai SUDS families (18 BS-positive subjects as the cases, and 27 BS-negatives as the controls). We found that the HLA-DRB1*12021 allele was significantly increased in BS-positive subjects (p=0.02; OR=4.5), the same as the HLA-DRB1*12021-DQB1*0301/09 haplotype (p=0.01; OR=7.95). Our data suggests that the HLA-DRB1*12021 allele associated with BS and the HLA-DRB1*12021-DQB1*0301/09 is a haplotype susceptible to arrhythmogenic markers that can identify a high risk for SUDS.

Revue / Journal Title

Southeast Asian journal of tropical medicine and public health    ISSN  0125-1562   CODEN SJTMAK 

Source / Source

2006, vol. 37, no2, pp. 357-365 [9 page(s) (article)] (1 p.1/4)

Langue / Language

Anglais

Editeur / Publisher

SEAMO, Regional Tropical Medicine and Public Health Network, Bangkok, THAILANDE  (1970) (Revue)

Localisation / Location

INIST-CNRS, Cote INIST : 19778, 35400013885935.0190

Nº notice refdoc (ud4) : 17925742



Faire une nouvelle recherche
Make a new search
Lancer la recherche
Bas