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Titre du document / Document title

Butyrate, a small pleiotropic molecule with multiple cellular and molecular actions : Its role as an anti-atherogenic agent

Auteur(s) / Author(s)

RANGANNA Kasturi (1) ; YATSU Frank M. (2) ; HAYES Barbara E. (1) ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

(1) College of Pharmacy, Texas Southern University, Houston Texas 77004, ETATS-UNIS
(2) Department Of Neurology, University of Texas Health Science Center at Houston, Houston, Texas, ETATS-UNIS

Résumé / Abstract

Evidence from various epidemiological and interventional studies has increased our awareness of the importance of diet and nutrition in human health and disease. Among the dietary habits, intake of high fiber diets has been linked to protection against chronic diseases such as cardiovascular disease, cancer, diabetes, obesity and neurological disorders, particularly atherosclerotic vascular disease and colorectal cancer. Butyrate, a natural bacterial fermentation product of dietary fiber produced in the mammalian colon, appears to mediate the protective role of a high fiber diet. In vitro studies have revealed that butyrate elicits many cytoprotective responses, which include stimulation of cell differentiation, arrest of cell proliferation, enhancement of the anti-inflammatory response, induction ofapoptosis, up-regulation of the anti-oxidant system, and down-regulation ofangiogenesis. However, it is not clear how this simple four-carbon molecule achieves these multiple effects to prevent colorectal cancer and offer protection against atherosclerotic vascular diseases and other chronic diseases. Recent advances in chromatin biology indicate that butyrate stimulates chromatin remodeling through its action as an inhibitor of histone deacetylase. Although extensive evidence supporting butyrate as an anti-cancer agent is available, few studies have investigated the role of butyrate as an anti-atherogenic agent whereby butyrate inhibits vascular smooth muscle cell proliferation, a critical element in the development of atherosclerosis. In this review, studies seeking to delineate butyrate's different mechanisms of actions in various cell types are reviewed in an attempt to understand butyrate's role in disease prevention. Particular emphasis is placed on describing the studies that have utilized post-genomic technologies, which allow characterization of cell-specific molecular responses to butyrate, and on describing the role of butyrate in disease prevention, specifically vascular proliferative diseases.

Source / Source

Recent research developments in molecular and cellular biochemistry :   ( Volume 2 (2005). Part I )
2005  , pp. 123-151[Note(s) :  [177 p.]] [Document : 29 p.] (118 ref.), [Notes: Résumés en début de chapitres] ISBN 81-7736-294-1 ;  Illustration : Illustration ;

Langue / Language

Anglais

Editeur / Publisher

Research signpost, Trivandrum, INDE  (2005) (Monographie)

Mots-clés anglais / English Keywords

Vascular disease

;

Cardiovascular disease

;

Atherosclerosis

;

Prevention

;

Review

;

Butyrate

;

Mots-clés français / French Keywords

Vaisseau sanguin pathologie

;

Appareil circulatoire pathologie

;

Athérosclérose

;

Prévention

;

Article synthèse

;

Butyrate

;

Mots-clés espagnols / Spanish Keywords

Vaso sanguíneo patología

;

Aparato circulatorio patología

;

Ateroesclerosis

;

Prevención

;

Artículo síntesis

;

Butirato

;

Localisation / Location

INIST-CNRS, Cote INIST : L 30425, 35400013879060.0070

Nº notice refdoc (ud4) : 17893322



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