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Titre du document / Document title

Protective properties of idebenone in noise-induced hearing loss in the guinea pig

Auteur(s) / Author(s)

SERGI Bruno (1) ; FETONI Anna Rita (1) ; PALUDETTI Gaetano (1) ; FERRARESI Aldo (2) ; NAVARRA Pierluigi (3) ; MORDENTE Alvaro (4) ; TROIANI Diana (2) ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

(1) Institute of Otolaryngology, School of Medicine, Catholic University, Rome, ITALIE
(2) Institute of Human Physiology, School of Medicine, Catholic University, Rome, ITALIE
(3) Institute of Pharmacology, School of Medicine, Catholic University, Rome, ITALIE
(4) Institute of Biochemistry, School of Medicine, Catholic University, Rome, ITALIE

Résumé / Abstract

Idebenone is a synthetic analogue of coenzyme Q10 with antioxidant properties. The present study investigated the antioxidant activity of idebenone in the rescue of acoustic trauma. Noise-induced hearing loss was induced by exposing guinea pigs to a continuous pure tone and idebenone was injected intraperitoneally I h before noise exposure and once daily for 3 days. Guinea pigs treated with idebenone showed significantly smaller auditory threshold shifts than unprotected control animals. Missing and apoptotic cells were identified with scanning electron microscopy and terminal deoxynucleotidyl transferase-mediated dUTP nick end labelling assay. Protected animals presented a lesser extent of both apoptotic activation and hair cell loss in the organ of Corti. Our results suggest an antioxidant function of idebenone in protection from noise-induced hearing loss and provide a rationale for exploring therapeutic strategies in humans.

Revue / Journal Title

Neuroreport    ISSN  0959-4965 

Source / Source

2006, vol. 17, no9, pp. 857-861 [5 page(s) (article)] (19 ref.)

Langue / Language

Anglais

Editeur / Publisher

Lippincott Williams & Wilkins, Hagerstown, MD, ETATS-UNIS  (1990) (Revue)

Mots-clés anglais / English Keywords

Vertebrata

;

Mammalia

;

Rodentia

;

Internal ear disease

;

Auditory disorder

;

ENT disease

;

Neuroprotective agent

;

Guinea pig

;

Neuroprotection

;

Antioxidant

;

Acoustic trauma

;

Hearing loss

;

Noise

;

Idebenone

;

Mots-clés français / French Keywords

Vertebrata

;

Mammalia

;

Rodentia

;

Oreille interne pathologie

;

Trouble audition

;

ORL pathologie

;

Neuroprotecteur

;

Cobaye

;

Neuroprotection

;

Antioxydant

;

Trouble dû au bruit

;

Surdité

;

Bruit

;

Idébénone

;

Mots-clés espagnols / Spanish Keywords

Vertebrata

;

Mammalia

;

Rodentia

;

Oido interno patología

;

Trastorno auditivo

;

ORL patología

;

Neuroprotector

;

Cobayo

;

Neuroprotección

;

Antioxidante

;

Trastorno por ruido

;

Sordera

;

Ruido

;

Idebenona

;

Mots-clés d'auteur / Author Keywords

acoustic trauma

;

antioxidants

;

idebenone

;

neuroprotection

;

noise-induced hearing loss

;

Localisation / Location

INIST-CNRS, Cote INIST : 22534, 35400011567410.0020

Nº notice refdoc (ud4) : 17863524



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