Titre du document / Document title
Osteoarthritis : Pathobiology-targets and ways for therapeutic intervention
Auteur(s) / Author(s)
AIGNER T. (1) ;
SACHSE A. (2) ;
GEBHARD P. M. (1) ;
ROACH H. I. (3) ;
Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)
(1) Institute of Pathology, University of Leipzig, Liebigstrasse 26, 04103 Leipzig, ALLEMAGNE
(2) Department of Orthopedics, University of Jena, Klosterlausnitzerstr. 81, 07607 Eisenberg, ALLEMAGNE
(3) Bone and Joint Research Group, Division of Developmental Origins of Health and Disease, University of Southampton, CF86, MP 817, General Hospital, Southampton, SO16 6YD, ROYAUME-UNI
Résumé / Abstract
Osteoarthritis is first and foremost the ongoing destruction of the articular cartilages of joints. Therefore, the extracellular matrix and the cells of the articular cartilages are the primary targets of osteoarthritis therapy. This tries to inhibit enzymatic destruction of the extracellular cartilage matrix as well as the modification of the cellular phenotype of the chondrocytes: cell degeneration and cell death are alongside anabolic activation and stabilization of the cellular phenotype of major interest. However, apart from the cartilage and its cells, other tissues of the joints are also important for the symptoms of the disease, which basically all originate outside the articular cartilage. In addition, changes in the subchondral bone as well as the synovial capsule and membrane are important at least for the progression of the disease process. All the named tissues offer different directions and ways for therapeutic intervention.
Revue / Journal Title
Advanced drug delivery reviews
ISSN
0169-409X
Source / Source
2006, vol. 58, n
o 2 (221 p.) [Document : 22 p.] (169 ref.), pp. 128-149 [22 page(s) (article)]
Langue / Language
Anglais
Editeur / Publisher
Elsevier, Kidlington, ROYAUME-UNI
(1987)
(Revue)
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Localisation / Location
INIST-CNRS, Cote INIST : 21718, 35400014258983.0020
Nº notice refdoc (ud4) : 17803443
