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Titre du document / Document title

Osteoarthritis : Pathobiology-targets and ways for therapeutic intervention

Auteur(s) / Author(s)

AIGNER T. (1) ; SACHSE A. (2) ; GEBHARD P. M. (1) ; ROACH H. I. (3) ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

(1) Institute of Pathology, University of Leipzig, Liebigstrasse 26, 04103 Leipzig, ALLEMAGNE
(2) Department of Orthopedics, University of Jena, Klosterlausnitzerstr. 81, 07607 Eisenberg, ALLEMAGNE
(3) Bone and Joint Research Group, Division of Developmental Origins of Health and Disease, University of Southampton, CF86, MP 817, General Hospital, Southampton, SO16 6YD, ROYAUME-UNI

Résumé / Abstract

Osteoarthritis is first and foremost the ongoing destruction of the articular cartilages of joints. Therefore, the extracellular matrix and the cells of the articular cartilages are the primary targets of osteoarthritis therapy. This tries to inhibit enzymatic destruction of the extracellular cartilage matrix as well as the modification of the cellular phenotype of the chondrocytes: cell degeneration and cell death are alongside anabolic activation and stabilization of the cellular phenotype of major interest. However, apart from the cartilage and its cells, other tissues of the joints are also important for the symptoms of the disease, which basically all originate outside the articular cartilage. In addition, changes in the subchondral bone as well as the synovial capsule and membrane are important at least for the progression of the disease process. All the named tissues offer different directions and ways for therapeutic intervention.

Revue / Journal Title

Advanced drug delivery reviews    ISSN  0169-409X 

Source / Source

2006, vol. 58, no 2 (221 p.)  [Document : 22 p.] (169 ref.), pp. 128-149 [22 page(s) (article)]

Langue / Language

Anglais

Editeur / Publisher

Elsevier, Kidlington, ROYAUME-UNI  (1987) (Revue)

Mots-clés anglais / English Keywords

Diseases of the osteoarticular system

;

Degenerative disease

;

Arthropathy

;

Pharmaceutical technology

;

Regeneration

;

Senescence

;

Drug

;

Cartilage

;

Treatment

;

Target

;

Osteoarthritis

;

Mots-clés français / French Keywords

Système ostéoarticulaire pathologie

;

Maladie dégénérative

;

Arthropathie

;

Technologie pharmaceutique

;

Régénération

;

Sénescence

;

Médicament

;

Cartilage

;

Traitement

;

Cible

;

Arthrose

;

Mots-clés espagnols / Spanish Keywords

Sistema osteoarticular patología

;

Enfermedad degenerativa

;

Artropatía

;

Tecnología farmacéutica

;

Regeneración

;

Senescencia

;

Medicamento

;

Cartílago

;

Tratamiento

;

Blanco

;

Artrosis

;

Mots-clés d'auteur / Author Keywords

Cartilage

;

Drugs

;

Joints

;

Chondrocytes

;

Senescence

;

Cartilage regeneration

;

Localisation / Location

INIST-CNRS, Cote INIST : 21718, 35400014258983.0020

Nº notice refdoc (ud4) : 17803443



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