Titre du document / Document title

Markers of inflammation and prediction of diabetes mellitus in adults (Atherosclerosis Risk in Communities Study): a cohort study

Auteur(s) / Author(s)

ARIC Investigators
SCHMIDT M. I. ^{(1 2)} ; DUNCAN B. B. ^{(1 2)} ; SHARRETT A. R. ⁽³⁾ ; LINDBERG G. ⁽⁴⁾ ; SAVAGE P. J. ⁽³⁾ ; OFFENBACHER S. ⁽⁵⁾ ; AZAMBUJA M. I. ⁽¹⁾ ; TRACY R. P. ⁽⁶⁾ ; HEISS G. ⁽²⁾ ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ Department of Social Medicine, School of Medicine, Federal University of Rio Grande do Sul, Porto Alegre, BRESIL
⁽²⁾ Department of Epldemiology, School of Public Health, University of North Carolina, Chapel Hill, NC, ETATS-UNIS
⁽³⁾ Division of Epidemiology and Clinlcal Applications, National Heart, Lung, and Blood Institute, Bethesda, MD, ETATS-UNIS
⁽⁴⁾ The NEPI Foundation, Malmo Hospital, Malmo, SUEDE
⁽⁵⁾ Dental Research Center, School of Dentistry, University of North Carolina, Chapel Hill, NC, ETATS-UNIS
⁽⁶⁾ Department of Pathology and Blochemistry, University of Vermont, Colchester, VT, ETATS-UNIS

Résumé / Abstract

Background Type 2 diabetes mellitus and atherosclerotic cardiovascular disease have common antecedents. Since markers of inflammation predict coronary heart disease and are raised in patients with type 2 diabetes, we investigated whether they predict whether people will develop type 2 diabetes. Methods 12 330 men and women, aged 45-64 years, were followed up for a mean of 7 years. We analysed the association between different markers of acute inflammation and subsequent diagnosis of diabetes. In a subgroup of 610 individuals selected originally for an unrelated atherosclerosis case-control study, we also investigated diabetes associations with total sialic acid and orosomucoid, haptoglobin, and α₁-antitrypsin. Findings 1335 individuals had a new diagnosis of diabetes. Adjusted odds ratios for developing diabetes for quartile extremes were 1.9 (95% CI 1.6-2.3) for raised white-cell count, 1.3 (1.0-1.5) for low serum albumin, and 1.2 (1.0-1.5) for raised fibrinogen. In the subgroup analysis, individuals with concentrations of orosomucoid and sialic acid of more than the median had odds ratios of 7.9 (2.6-23.7) and 3.7 (1.4-9.8), respectively. Adjustment for body-mass index and waist-to-hip ratio lessened the associations; those for white-cell count (1.5 [1.3-1.8]), orosomucoid (7.1 [2.1-23.7]), and sialic acid (2.8 [1.0-8.1]) remained significant. interpretation Markers of inflammation are associated with the development of diabetes in middle-aged adults. Although autoimmunity may partly explain these associations, they probably reflect the pathogenesis of type 2 diabetes.

Revue / Journal Title

Lancet   ISSN 0140-6736   CODEN LANCAO 

Source / Source

1999, vol. 353, n^o9165, pp. 1649-1652 (30 ref.)

Langue / Language

Anglais

Editeur / Publisher

Lancet, London, ROYAUME-UNI  (1823) (Revue)

Mots-clés anglais / English Keywords

Non insulin dependent diabetes ; Atherosclerosis ; Inflammation ; Biological marker ; Predictive value ; Cohort study ; Human ; Female ; Endocrinopathy ; Cardiovascular disease ; Vascular disease ;

Mots-clés français / French Keywords

Diabète non insulinodépendant ; Athérosclérose ; Inflammation ; Marqueur biologique ; Valeur prédictive ; Etude cohorte ; Homme ; Femelle ; Endocrinopathie ; Appareil circulatoire pathologie ; Vaisseau sanguin pathologie ;

Mots-clés espagnols / Spanish Keywords

Diabetes no insulinodependiente ; Ateroesclerosis ; Inflamación ; Marcador biológico ; Valor predictivo ; Estudio cohorte ; Hombre ; Hembra ; Endocrinopatía ; Aparato circulatorio patología ; Vaso sanguíneo patología ;

Localisation / Location

INIST-CNRS, Cote INIST : 5004, 35400008450893.0080