Titre du document / Document title
Glucose-stimulated insulin secretion : Insights from modelling
Auteur(s) / Author(s)
WESTERMARK Pal O.
(1) ;
HELLGREN KOTALESKI Jeanette
(1) ;
LANSNER Anders
(1) ;
Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)
(1) SANYPSCI, NADA, Royal institute of technology (KTH), 10044 Stockholm, SUEDE
Résumé / Abstract
Insulin is secreted by the pancreatic β-cells in response to a raised blood glucose concentration. Glucose-stimulated insulin secretion (GSIS) is pulsatile and correlated with bursting electrical activity. We review the current understanding of pancreatic p-cell GSIS from a mathematical modelling perspective. We discuss the glycolysis and the mitochondrial metabolism and metabolic modelling thereof. In particular, we describe the theoretical basis for the hypothesis of an oscillatory glycolysis, which may be the cause of the pulsatile secretion. We also discuss the electrophysiology of the P-cell and present insights gained from mathematical modelling in this context. There are important causal connections between β-cell metabolism and electrophysiology. This brings about an unusual challenge for theoretical and computational biologists.
Revue / Journal Title
Recent research developments in biophysics
Source / Source
Recent research developments in biophysics vol. 3 - 2004 Part II
2004
, vol. vol. 3, 2004, pp. 325-350[Note(s) : [293 p.]] [Document : 26 p.] (131 ref.)
Illustration : Illustration
;
Langue / Language
Anglais
Editeur / Publisher
Transworld Research Signpost, Trivandrum, INDE
(2004)
(Monographie)
Mots-clés anglais / English Keywords
Pancreatic hormone ;
Mathematical model ;
Electrophysiology ;
Review ;
Stimulation ;
Secretion ;
Insulin ;
Glucose ;
Mots-clés français / French Keywords
Hormone pancréatique ;
Modèle mathématique ;
Electrophysiologie ;
Article synthèse ;
Stimulation ;
Sécrétion ;
Insuline ;
Glucose ;
Mots-clés espagnols / Spanish Keywords
Hormona pancreática ;
Modelo matemático ;
Electrofisiología ;
Artículo síntesis ;
Estimulación ;
Secreción ;
Insulina ;
Glucosa ;
Localisation / Location
INIST-CNRS, Cote INIST : L 29983, 35400013864351.0060
Nº notice refdoc (ud4) : 17751724
