Titre du document / Document title

Pharmacological evaluation of Pachyrrhizus erosus (L) seeds for central nervous system depressant activity

Auteur(s) / Author(s)

ABID Mohd ; HRISHIKESHAVAN H. J. ; ASAD Mohammed ;

Résumé / Abstract

The research work deals with the screening of ethanol and chloroform extracts of Pachyrrhizus erosus seeds for central nervous system (CNS) depressant activity. The Pachyrrhizus erosus seed is known to contain rotinoids, flavonoids and phenylfuranocoumarin derivatives as chemical components and is reported to have antifungal, antisecretory, insecticides, antibacterial and spasmolytic activity. Since seeds of Pachyrrhizus erosus is used as folk medicine in treatment of insomnia, we made an attempt to study its CNS depressant effect. The different activities studied were potentiation of pentobarbitone-induced sleep, test for locomotor activity, effect on muscle co-ordination, antiaggressive and antianxiety activities. The result of the study reflected that ethanol extract of the seeds (150 mg/kg, p.o) decreased locomotor activity, produced muscle relaxation and showed antianxiety and antiaggressive activity.

Revue / Journal Title

Indian Journal of Physiology and Pharmacology    ISSN  0019-5499 

Source / Source

2006, vol. 50, n^o2, pp. 143-151 [9 page(s) (article)]

Langue / Language

Anglais

Editeur / Publisher

All India Institute of Medical Sciences, Department of Physiology, New Delhi, INDE  (1957) (Revue)

Localisation / Location

INIST-CNRS, Cote INIST : 13002, 35400015320634.0050