Titre du document / Document title

Pharmacokinetics and bioavailability of acyclovir sustained-release tablets in dogs

Auteur(s) / Author(s)

QING YANG ⁽¹⁾ ; QIN HU ⁽¹⁾ ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ Department of Pharmacy, Nanjing Medical University, Nanjing, Jiangsu, CHINE

Résumé / Abstract

The pharmacokinetics and bioavailability of acyclovir sustained-release tablets in dogs were investigated. Blood concentrations of acyclovir were determined by RP-HPLC after a single oral dose of two kinds of acyclovir tablets given separately to 6 beagle dogs. The main pharmacokinetics parameters of the acyclovir sustained-release tablet were as follows: T_1/2, T_max and C_max were 4.10±0.20 h, 4.05±0.54 h and 6.90±0.68 μg·ml^-1, respectively. MRT was 9.02±0.44 h. Using acyclovir standard tablet as control, relative bioavailability of the acyclovir sustained-release tablet was 152.2±49.90 %. According to the two-tailed t-test, there was a distinct difference in the data for T_max, C_max and AUC between acyclovir sustained-release tablets and acyclovir standard tablets, and the absorbability of acyclovir sustained-release tablets was much better than that of the acyclovir standard tablets.

Revue / Journal Title

European journal of drug metabolism and pharmacokinetics   ISSN 0378-7966 

Source / Source

2006, vol. 31, n^o1, pp. 17-20 [4 page(s) (article)] (4 ref.)

Langue / Language

Anglais

Editeur / Publisher

Médecine et hygiène, Genève, SUISSE  (1976) (Revue)

Mots-clés anglais / English Keywords

Dosage form ; Nucleoside analog ; Purine nucleoside ; Acyclic nucleoside ; Vertebrata ; Mammalia ; Carnivora ; Fissipedia ; HPLC chromatography ; Dog ; Animal ; Tablet ; Controlled release form ; Antiviral ; Aciclovir ; Bioavailability ; Pharmacokinetics ;

Mots-clés français / French Keywords

Forme pharmaceutique ; Analogue nucléoside ; Purine nucléoside ; Nucléoside acyclique ; Vertebrata ; Mammalia ; Carnivora ; Fissipedia ; Chromatographie HPLC ; Chien ; Animal ; Comprimé ; Forme libération contrôlée ; Antiviral ; Aciclovir ; Biodisponibilité ; Pharmacocinétique ;

Mots-clés espagnols / Spanish Keywords

Forma farmacéutica ; Análogo nucleósido ; Purina nucleósido ; Nucleósido acíclico ; Vertebrata ; Mammalia ; Carnivora ; Fissipedia ; Cromatografía HPLC ; Perro ; Animal ; Tableta ; Forma liberación controlada ; Antiviral ; Aciclovir ; Biodisponibilidad ; Farmacocinética ;

Mots-clés d'auteur / Author Keywords

Acyclovir ; pharmacokinetics ; bioavailability ; HPLC ;

Localisation / Location

INIST-CNRS, Cote INIST : 16876, 35400014268776.0040