Titre du document / Document title

Herpes simplex virus type 1 colitis in a patient with common variable immunodeficiency syndrome

Auteur(s) / Author(s)

DRAY Xavier ⁽¹⁾ ; TRETON Xavier ⁽¹⁾ ; MAZERON Marie-Christine ⁽²⁾ ; LAVERGNE-SLOVE Anne ⁽³⁾ ; JOLY Francisca ⁽¹⁾ ; MIMRAM Dora ⁽⁴⁾ ; ATTAR Alain ⁽⁵⁾ ; TOBELEM Gerard ⁽⁶⁾ ; BOUHNIK Yoram ⁽¹⁾ ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ Service de Gastroenterologie et d'Assistance Nutritive, Hôpital Lariboisidre, Paris, FRANCE
⁽²⁾ Laboratoire de Bacteriologie-Virologie, Hôpital Lariboisidre, Paris, FRANCE
⁽³⁾ Service Central d'Anatomie et Cytologie Pathologiques, Hôpital Lariboisidre, Paris, FRANCE
⁽⁴⁾ GastroLouvre, Paris, FRANCE
⁽⁵⁾ Service de Gastroenterologie, Hôpital Avicenne, Bobigny, FRANCE
⁽⁶⁾ Service d'Hématologie, Hopital Lariboisiere, Paris, FRANCE

Résumé / Abstract

We report on a case of herpes simplex virus (HSV) type 1 colitis in a 69-year-old patient with common variable immunodeficiency syndrome. A treatment with polyvalent immunoglobulins was discontinued in April 2001. In March 2004 she developed chronic diarrhoea related to rectosigmoidal and caecal ulcerations. In November 2004, HSV was recovered in tissue culture from colonic biopsies. Valaciclovir was then started, leading the patient to clinical remission at day 4, and continued for a 6-week course (without any secondary antiviral prophylaxis). Colonic biopsies were negative for HSV by tissue culture and PCR within 3 weeks of antiviral treatment Intravenous polyvalent immunoglobulin infusions were readministered within the third week of antiviral treatment. She has declared no clinical event since this period. Three months after the antiviral treatment was achieved, a rectosigmoidoscopy showed an ad-integrum macroscopic and histological mucosal healing whereas PCR was negative for HSV In the colonic tissue. As a large proportion of patients with common variable immunodeficiency syndrome present not only as a humoral immunodeficiency but also as a defect in the cellular immunity compartment (with T-cell deficits), HSV, as well as cytomegalovirus, should be investigated in patients with common variable immunodeficiency syndrome presenting colitis.

Revue / Journal Title

European journal of gastroenterology & hepatology   ISSN 0954-691X 

Source / Source

2006, vol. 18, n^o5, pp. 541-544 [4 page(s) (article)] (21 ref.)

Langue / Language

Anglais

Editeur / Publisher

Lippincott Williams & Wilkins, Hagerstown, MD, ETATS-UNIS  (1989) (Revue)

Mots-clés anglais / English Keywords

Gastric disease ; Intestinal disease ; Betaherpesvirinae ; Virus ; Herpesviridae ; Alphaherpesvirinae ; Infection ; Gastroenterology ; Enterocolitis ; Gastroenteritis ; Gastrointestinal diseases ; Digestive diseases ; Digestive system ; Deficiency ; Immune system ; Herpes ; DNA ; Common variable immunodeficiency ; Cytomegalovirus ; Human ; Colitis ; Herpesvirus hominis ; Viral disease ;

Mots-clés français / French Keywords

Estomac pathologie ; Intestin pathologie ; Betaherpesvirinae ; Virus ; Herpesviridae ; Alphaherpesvirinae ; Infection ; Gastroentérologie ; Entérocolite ; Gastroentérite ; Tube digestif pathologie ; Appareil digestif pathologie ; Appareil digestif ; Déficit ; Système immunitaire ; Herpès ; DNA ; Immunodéficit commun variable ; Cytomegalovirus ; Homme ; Colite ; Herpesvirus hominis ; Virose ;

Mots-clés espagnols / Spanish Keywords

Estómago patología ; Intestino patología ; Betaherpesvirinae ; Virus ; Herpesviridae ; Alphaherpesvirinae ; Infección ; Gastroenterología ; Enterocolitis ; Gastroenteritis ; Tubo digestivo patología ; Aparato digestivo patología ; Aparato digestivo ; Déficiencia ; Sistema inmunitario ; Herpes ; DNA ; Inmunodefícito común variable ; Cytomegalovirus ; Hombre ; Colitis ; Herpesvirus hominis ; Virosis ;

Mots-clés d'auteur / Author Keywords

viruses ; DNA viruses ; herpes virldae ; alpha herpes virinae ; herpes simplex ; beta herpes virinae ; cytomegalovirus ; Immune system diseases ; immunologlcal deficiency syndromes ; common variable Immunodeficiency ; digestive system diseases ; gastrointestinal diseases ; gastroenteritis ; enterocolitis ;

Localisation / Location

INIST-CNRS, Cote INIST : 22107, 35400015674261.0150