Titre du document / Document title

Fabrication and characterization of microfluidic probes for convection enhanced drug delivery

Auteur(s) / Author(s)

NEEVES K. B. ⁽¹⁾ ; LO C. T. ⁽²⁾ ; FOLEY C. P. ⁽¹⁾ ; SALTZMAN W. M. ⁽²⁾ ; OLBRICHT W. L. ⁽¹⁾ ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ School of Chemical and Biomolecular Engineering, Cornell University, Ithaca, NY 14853, ETATS-UNIS
⁽²⁾ Department of Biomedical Engineering, Yale University, New Haven, CT 06520, ETATS-UNIS

Résumé / Abstract

Convection enhanced drug delivery (CED) is a promising therapeutic method for treating diseases of the brain by enhancing the penetration of drugs. Most controlled release delivery methods rely on diffusion from a source to transport drugs throughout tissue. CED relies on direct infusion of drugs into tissue at a sufficiently high rate so that convective transport of drug is at least as important as diffusive transport. This work describes the fabrication and characterization of microfluidic probes for CED protocols and the role diffusion plays in determining penetration. Microfluidic channels were formed on silicon substrates by employing a sacrificial photoresist layer encased in a parylene structural layer. Flow in the microchannels was characterized by applying constant upstream pressures from 35 to 310 kPa, which resulted in flow rates of 0.5-4.5 μL/min. The devices were used to infuse Evans Blue and albumin in hydrogel brain phantoms. The results of these infusions were compared to a simple convection-diffusion model for infusions into porous media. In vivo infusions of albumin were performed in the gray matter of rats at upstream pressures of 35, 70, and 140 kPa. The microfabricated probes show reduced evidence of backflow along the device-tissue interface when compared with conventional needles used for CED.

Revue / Journal Title

Journal of controlled release   ISSN 0168-3659   CODEN JCREEC 

Source / Source

2006, vol. 111, n^o3, pp. 252-262 [11 page(s) (article)] (51 ref.)

Langue / Language

Anglais

Editeur / Publisher

Elsevier, Amsterdam, PAYS-BAS  (1984) (Revue)

Mots-clés anglais / English Keywords

Pharmaceutical technology ; Diffusion ; Encephalon ; Drug ; Probe ; Characterization ;

Mots-clés français / French Keywords

Technologie pharmaceutique ; Diffusion ; Encéphale ; Médicament ; Sonde ; Caractérisation ;

Mots-clés espagnols / Spanish Keywords

Tecnología farmacéutica ; Difusión ; Encéfalo ; Medicamento ; Sonda ; Caracterización ;

Mots-clés d'auteur / Author Keywords

Convection enhanced delivery ; Microfluidics ; Microfabrication ; Brain ; Convection-diffusion model ;

Localisation / Location

INIST-CNRS, Cote INIST : 20704, 35400014272349.0010