Titre du document / Document title

Obviation of opioid withdrawal syndrome by concomitant administration of naltrexone in microgram doses : Two psychonautic bioassays

Auteur(s) / Author(s)

OTT Jonathan ⁽¹⁾ ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ Entheobotanica, Solothum, SUISSE

Résumé / Abstract

Two psychonautic bioassays (self-experiments) in stepwise and abrupt cessation of long-term daily oral ingestion habits of 800 mg of codeine phosphate are presented. Concomitant administration of minute doses (about 0.5 mcg) of the opioid antagonist naltrexone with each dose of codeine was found in both cases to obviate the expected opioid withdrawal syndrome, resulting in asymptomatic and uneventful transitions from physical opioid dependency states to exogenous opioid-free metabolism. These experiments are analyzed in the context of a conjectured, rapid, iterative reduction and complete elimination of opioid tolerance, once acquired. It was found that coadministration of naltrexone with codeine phosphate obviated the development of both tolerance and physical dependency over several months of four daily oral doses of 200 mg, allowing abrupt ("cold turkey"), asymptomatic and uneventful withdrawal. This points the way to the biochemical substrate of opioid tolerance itself, and shows that this can easily and inexpensively be blocked, even over months of iterative oral administration of substantial doses of opioid analgesics. Finally, it suggests the opioid withdrawal syndrome is directly related to the physiology of opioid tolerance, and can be prevented by blocking tolerance itself. Even when tolerance has been acquired, this can be reduced stepwise over a matter of days, with no symptoms of opioid withdrawal syndrome.

Revue / Journal Title

Journal of psychoactive drugs   ISSN 0279-1072   CODEN JPDRD3 

Source / Source

2006, vol. 38, n^o1, pp. 101-105 [5 page(s) (article)] (11 ref.)

Langue / Language

Anglais

Editeur / Publisher

Haight-Ashbury, San Francisco, CA, ETATS-UNIS  (1981) (Revue)

Mots-clés anglais / English Keywords

Morphinan derivatives ; Narcotic analgesic ; Psychology ; Psychiatry ; Pharmacology ; Human ; Tolerance ; Drug of abuse ; Dose ; Poison withdrawal ; Replacement therapy ; Naltrexone ; Addiction ; Withdrawal syndrome ; Opiates ; Drug addiction ;

Mots-clés français / French Keywords

Morphinane dérivé ; Analgésique narcotique ; Psychologie ; Psychiatrie ; Pharmacologie ; Homme ; Tolérance ; Substance toxicomanogène ; Dose ; Sevrage toxique ; Codéine ; Traitement substitutif ; Naltrexone ; Addiction ; Sevrage syndrome ; Opiacés ; Toxicomanie ;

Mots-clés espagnols / Spanish Keywords

Morphinano derivado ; Analgésico narcotico ; Psicología ; Psiquiatría ; Farmacología ; Hombre ; Tolerancia ; Sustancia toxicomanógena ; Dosis ; Destete tóxico ; Tratamiento sustitutivo ; Naltrexona ; Adicción ; Destete síndrome ; Opiados ; Toxicomanía ;

Mots-clés d'auteur / Author Keywords

addiction ; codeine ; naltrexone ; opioids ; tolerance ; withdrawal ;

Localisation / Location

INIST-CNRS, Cote INIST : 14614, 35400015676043.0120