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Titre du document / Document title

Meta-analysis : colorectal and small bowel cancer risk in patients with Crohn's disease

Auteur(s) / Author(s)

CANAVAN C. (1) ; ABRAMS K. R. (2) ; MAYBERRY J. (1) ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

(1) Digestive Diseases Centre, University Hospitals of Leicester, Leicester General Hospital, Leicester, ROYAUME-UNI
(2) Centre for Biostatistics and Genetic Epidemiology, Department of Heath Sciences, University of Leicester, Leicester, ROYAUME-UNI

Résumé / Abstract

Background Crohn's disease is associated with small bowel cancer whilst risk of colorectal cancer is less clear. Aim To ascertain the combined estimates of relative risk of these cancers in Crohn's disease. Methods MEDLINE was searched to identify relevant papers. Exploding references identified additional publications. When two papers reviewed the same cohort, the later study was used. Results Meta-analysis showed overall colorectal cancer relative risk in Crohn's disease as 2.5 (1.3-4.7), 4.5 (1.3-14.9) for patients with colonic disease and 1.1 (0.8-1.5) in ileal disease. Meta-regression showed reduction in relative risk over the past 30 years. Subgroup analysis showed Scandinavia had significantly lower colorectal cancer relative risk than the UK and North America. Cumulative risk analysis showed 10 years following diagnosis of Crohn's disease relative risk of colorectal cancer is 2.9% (1.5%-5.3%). Meta-analysis showed small bowel cancer relative risk in Crohn's disease is 33.2 (15.9-60.9). Small bowel cancer relative risk has not significantly reduced over the last 30 years. Conclusion Relative risk of colorectal and small bowel cancers are significantly raised in Crohn's disease. Cumulative risk of colorectal cancer of 2.9% at 10 years suggests a potential benefit from routine screening. However, the value of screening requires rigorous appraisal.

Revue / Journal Title

Alimentary pharmacology & therapeutics    ISSN  0269-2813 

Source / Source

2006, vol. 23, no8, pp. 1097-1104 [8 page(s) (article)] (41 ref.)

Langue / Language

Anglais

Editeur / Publisher

Blackwell, Oxford, ROYAUME-UNI  (1987) (Revue)

Mots-clés anglais / English Keywords

Inflammatory disease

;

Intestinal disease

;

Digestive diseases

;

Digestive system

;

Crohn disease

;

Human

;

Risk factor

;

Malignant tumor

;

Small intestine

;

Rectum

;

Colon

;

Metaanalysis

;

Mots-clés français / French Keywords

Maladie inflammatoire

;

Intestin pathologie

;

Appareil digestif pathologie

;

Appareil digestif

;

Entérite Crohn

;

Homme

;

Facteur risque

;

Tumeur maligne

;

Intestin grêle

;

Rectum

;

Côlon

;

Métaanalyse

;

Mots-clés espagnols / Spanish Keywords

Enfermedad inflamatoria

;

Intestino patología

;

Aparato digestivo patología

;

Aparato digestivo

;

Enteritis Crohn

;

Hombre

;

Factor riesgo

;

Tumor maligno

;

Intestino delgado

;

Recto

;

Colón

;

Meta-análisis

;

Localisation / Location

INIST-CNRS, Cote INIST : 21831, 35400015296834.0070

Nº notice refdoc (ud4) : 17660183



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