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Titre du document / Document title

Inhibition of early and late phase allergic reactions by Euphorbia hirta L

Auteur(s) / Author(s)

SINGH G. D. (1) ; KAISER P. (1) ; YOUSSOUF M. S. (1) ; SINGH S. (1) ; KHAJURIA A. (1) ; KOUL A. (1) ; BANI S. (1) ; KAPAHI B. K. (1) ; SATTI N. K. (1) ; SURI K. A. (1) ; JOHRI R. K. (1) ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

(1) Division of Pharmacology and Natural Products Chemistry, Regional Research Laboratory, Jammu-Tawi 180 001, INDE

Résumé / Abstract

A 95% ethanol extract from whole aerial parts of Euphorbia hirta (EH A001) showed antihistaminic, antiinflammatory and immunosuppressive properties in various animal models. EH A001 inhibited rat peritoneal mast cell degranulation triggered by compound 48/80. It significantly inhibited dextran-induced rat paw edema. EH A001 prevented eosinophil accumulation and eosinophil peroxidase activity and reduced the protein content in bronchoalveolar lavage fluid (BALF) in a 'mild' model of asthma. Moreover, the CD4/CD8 ratio in peripheral blood was suppressed. EH A001 attenuated the release of interleukin-4 (IL-4) and augmented interferon-y (IFN-y) in ovalbumin-sensitized mouse splenocytes. The results were compared with the effects of known compounds, ketotifen, cetirizine and cyclophosphamide. These findings demonstrated that Euphorbia hirta possessed significant activity to prevent early and late phase allergic reactions.

Revue / Journal Title

PTR. Phytotherapy research    ISSN  0951-418X 

Source / Source

2006, vol. 20, no4, pp. 316-321 [6 page(s) (article)] (27 ref.)

Langue / Language

Anglais

Editeur / Publisher

Wiley, Chichester, ROYAUME-UNI  (1987) (Revue)

Mots-clés anglais / English Keywords

Cytokine

;

Immunopathology

;

Enzyme

;

Oxidoreductases

;

Peroxidases

;

Spermatophyta

;

Angiospermae

;

Dicotyledones

;

Euphorbiaceae

;

Plant origin

;

Medicinal plant

;

Pharmacognosy

;

Immunosuppression

;

Edema

;

Peroxidase

;

Eosinophil

;

Gamma interferon

;

Interleukin 4

;

Histamine

;

Mast cell

;

Euphorbia hirta

;

Toxicity

;

Allergy

;

Late

;

Mots-clés français / French Keywords

Cytokine

;

Immunopathologie

;

Enzyme

;

Oxidoreductases

;

Peroxidases

;

Spermatophyta

;

Angiospermae

;

Dicotyledones

;

Euphorbiaceae

;

Origine végétale

;

Plante médicinale

;

Pharmacognosie

;

Immunodépression

;

Oedème

;

Peroxidase

;

Eosinophile

;

Interféron gamma

;

Interleukine 4

;

Histamine

;

Mastocyte

;

Euphorbia hirta

;

Toxicité

;

Allergie

;

Tardif

;

Mots-clés espagnols / Spanish Keywords

Citoquina

;

Inmunopatología

;

Enzima

;

Oxidoreductases

;

Peroxidases

;

Spermatophyta

;

Angiospermae

;

Dicotyledones

;

Euphorbiaceae

;

Origen vegetal

;

Planta medicinal

;

Farmacognosia

;

Inmunodepresión

;

Edema

;

Peroxidase

;

Eosinófilo

;

Interferón gamma

;

Interleuquina 4

;

Histamina

;

Mastocito

;

Euphorbia hirta

;

Toxicidad

;

Alergia

;

Tardío

;

Mots-clés d'auteur / Author Keywords

Euphorbia hirta L.; allergy; compound 48/80; peritoneal mast cells; histamine; interleukin-4; interferon-γ

;

eosinophils; eosinophil peroxidase; edema; immunosuppression

;

Localisation / Location

INIST-CNRS, Cote INIST : 21695, 35400015297071.0150

Nº notice refdoc (ud4) : 17641631



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