Titre du document / Document title

The influence of storage conditions on the polymorphic stability of zolpidem tartrate hydrate

Auteur(s) / Author(s)

LAWECKA Marta ⁽¹⁾ ; KOSMACINSKA Bozenna ⁽¹⁾ ; GLICE Magdalena ⁽¹⁾ ; KORCZAK Katarzyna ⁽¹⁾ ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ Pharmaceutical Research Institute, Rydygiera 8, 01-793 Warsaw, POLOGNE

Résumé / Abstract

The polymorphic stability of a drug substance is a very important topic in the pharmaceutical industry. Differential scanning calorimetry, thermogravimetric analysis with the support of X-ray powder diffraction and infrared spectroscopy were used as screening techniques for testing structural changes of zolpidem tartrate hydrate stored under different conditions. Obtained data suggested that first structural changes occurred at the temperature of 25°C after 2 months of storage. DSC analysis showed that there was a two-step process of water elimination and lack of a phase transition in the temperature range from 130 to 170°C in comparison with an initial sample.

Revue / Journal Title

Journal of thermal analysis and calorimetry   ISSN 1388-6150 

Source / Source

Congrès
European Conference on Calorimetry and Thermal Analysis for Environment ECCTAE 2005, Zakopane , POLOGNE (11/09/2005)
2006, vol. 83, n^o3, pp. 583-585 [3 page(s) (article)] (8 ref.)

Langue / Language

Anglais

Editeur / Publisher

Springer, Dordrecht, PAYS-BAS  (1998) (Revue)

Mots-clés anglais / English Keywords

Gabaergic agonist ; Gabaergic receptor A ; Agonist ; Thermal analysis ; Sedative ; Hypnotic ; Polymorphic transformation ; Tartrate ; X ray diffraction ; Thermogravimetry ; Infrared spectrometry ; Differential scanning calorimetry ; Drug ; Hydrates ; Zolpidem ; Structure stability ; Storage ;

Mots-clés français / French Keywords

Stimulant gabaergique ; Récepteur gabaergique A ; Agoniste ; Imidazo[1,2-a]pyridine dérivé ; Analyse thermique ; Sédatif ; Hypnotique ; Transformation polymorphique ; Tartrate ; Diffraction RX ; Thermogravimétrie ; Spectrométrie IR ; Calorimétrie différentielle balayage ; Médicament ; Hydrate ; Zolpidem ; Stabilité structurale ; Stockage ;

Mots-clés espagnols / Spanish Keywords

Estimulante gabaérgico ; Receptor gabaminérgico A ; Agonista ; Análisis térmico ; Sedante ; Hipnótico ; Transformación polimorfa ; Tartrato ; Difracción RX ; Termogravimetría ; Espectrometría IR ; Análisis calorimétrico barrido exploración ; Medicamento ; Hidrato ; Zolpidem ; Estabilidad estructural ; Almacenamiento ;

Mots-clés d'auteur / Author Keywords

drug substance ; DSC ; infrared spectroscopy (IR) ; polymorphic stability ; thermogravimetric analysis (TG/SDTA) ; X-ray powder diffraction (XRPD) ; zolpidem tartrate ;

Localisation / Location

INIST-CNRS, Cote INIST : 6367, 35400013247870.0110