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Titre du document / Document title

Apoptosis inhibitor, survivin, in posterior uveal melanoma : Comparison among primary tumors, tumors resistant to brachytherapy, tumors with liver metastases, and liver metastases

Auteur(s) / Author(s)

BEN SIMON Guy J. ; ABULAFIA Adi ; PE'ER Jacob ;

Résumé / Abstract

Purpose: To study the expression ofsurvivin, an apoptosis inhibitor protein, in human posterior uveal melanoma. Methods: Specimens were divided according to eyes with tumors that were enucleated primarily, those resistant to brachytherapy, eyes from patients with known liver metastases, and liver metastases. Results: There was only low expression of survivin in uveal melanoma. No difference in survivin positive cell counts per high power field (PCC/HPF) were found among tumors that were enucleated primarily (n = 33), tumors with previous brachytherapy (n = 29), tumors with liver metastases (n = 12) or liver metastases (n = 18). Corresponding counts were 11.8 (±14.3), 11.8 (±16.8), 7.1 (±11.2), and 4.7 (±8.8) in the four groups, respectively (p > 0.05). Half of the liver metastases showed no staining for survivin. Twenty patients (24%) had tumor-related death at the end of follow-up. Conclusions: Survivin is expressed in posterior uveal melanomas that were treated by enucleation, as well as in tumors that were previously treated with brachytherapy or liver metastases; however, its expression by immunostaining did not seem with correlate with the tumor biological activity.

Revue / Journal Title

Current eye research    ISSN  0271-3683   CODEN CEYRDM 

Source / Source

2006, vol. 31, no3, pp. 251-257 [7 page(s) (article)]

Langue / Language

Anglais

Editeur / Publisher

Swets & Zeitlinger, Lisse, PAYS-BAS  (1981) (Revue)

Mots-clés d'auteur / Author Keywords

brachytherapy

;

inhibitors of apoptosis

;

liver metastases

;

survivin

;

uveal melanoma

;

Localisation / Location

INIST-CNRS, Cote INIST : 19283, 35400013246526.0050

Nº notice refdoc (ud4) : 17615962



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