Titre du document / Document title
First-degree atrioventricular block in alprazolam overdose reversed by flumazenil
Auteur(s) / Author(s)
MULLINS M. E.
(1) ;
Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)
(1) Oregon Poison Center, Department of Emergency Medicine, Oregon Health Sciences University, Portland, Oregon, ETATS-UNIS
Résumé / Abstract
This report describes a case of alprazolam overdose associated with marked first-degree atrioventricular block reversed by flumazenil. Animal and human evidence suggests activity of certain benzodiazepines at peripheral benzodiazepine receptors in the myocardium and elsewhere. Myocardial benzodiazepine receptor ligands appear to affect calcium-channel activity, which may explain the clinical findings. Benzodiazepines may behave like weak calcium-channel blockers. This case raises the possibility of a potential role for flumazenil as an adjunct in the management of calcium-channel blocker toxicity.
Revue / Journal Title
Journal of pharmacy and pharmacology
ISSN 0022-3573
CODEN JPPMAB
Source / Source
1999, vol. 51, n
o3, pp. 367-370 (17 ref.)
Langue / Language
Anglais
Editeur / Publisher
Pharmaceutical Press, Wallingford, ROYAUME-UNI
(1949)
(Revue)
Mots-clés anglais / English Keywords
Flumazenil ;
Alprazolam ;
Antagonist ;
Benzodiazepine receptor ;
Benzodiazepine antagonist ;
Atrioventricular bloc ;
Toxicity ;
Overdose ;
Human ;
Case study ;
Tranquillizer ;
Psychotropic ;
Treatment ;
Chemotherapy ;
Benzodiazepine derivatives ;
Cardiovascular disease ;
Heart disease ;
Arrhythmia ;
Heart block ;
Conduction disorder ;
Mots-clés français / French Keywords
Flumazénil ;
Alprazolam ;
Antagoniste ;
Récepteur benzodiazépinique ;
Antagoniste benzodiazépine ;
Bloc auriculoventriculaire ;
Toxicité ;
Overdose ;
Homme ;
Etude cas ;
Tranquillisant ;
Psychotrope ;
Traitement ;
Chimiothérapie ;
Benzodiazépine dérivé ;
Appareil circulatoire pathologie ;
Cardiopathie ;
Trouble rythme cardiaque ;
Bloc cardiaque ;
Trouble conduction ;
Mots-clés espagnols / Spanish Keywords
Flumazenilo ;
Alprazolam ;
Antagonista ;
Receptor benzodiazepínico ;
Antagonista benzodiazepina ;
Bloqueo aurículoventricular ;
Toxicidad ;
Sobredosis ;
Hombre ;
Estudio caso ;
Tranquilizante ;
Psicotropo ;
Tratamiento ;
Quimioterapia ;
Benzodiazepina derivado ;
Aparato circulatorio patología ;
Cardiopatía ;
Arritmia ;
Bloque cardíaco ;
Trastorno conducción ;
Localisation / Location
INIST-CNRS, Cote INIST : 984, 35400008367642.0190
Nº notice refdoc (ud4) : 1759482
