Titre du document / Document title

Cardiovascular disease in the polycystic ovary syndrome : New insights and perspectives

Auteur(s) / Author(s)

CUSSONS Andrea J. ^{(1 2)} ; STUCKEY Bronwyn G. A. ^{(1 2 3)} ; WATTS Gerald F. ⁽²⁾ ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ Keogh Institute for Medical Research, Nedlands, WA, AUSTRALIE
⁽²⁾ University of Western Australia, School of Medicine & Pharmacology, Royal Perth Hospital Unit, GPO Box X2213, Perth, WA 6847, AUSTRALIE
⁽³⁾ Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Nedlands, WA, AUSTRALIE

Résumé / Abstract

The new millennium has brought intense focus of interest on the risk of cardiovascular disease in women. The polycystic ovary syndrome (PCOS) is a common endocrine disorder in women characterised by hyperandrogenism and oligomenorrhoea. Most women with PCOS also exhibit features of the metabolic syndrome, including insulin resistance, obesity and dyslipidaemia. While the association with type 2 diabetes is well established, whether the incidence of cardiovascular disease is increased in women with PCOS remains unclear. Echocardiography, imaging of coronary and carotid arteries, and assessments of both endothelial function and arterial stiffness have recently been employed to address this question. These studies have collectively demonstrated both structural and functional abnormalities of the cardiovascular system in PCOS. These alterations, however, appear to be related to the presence of individual cardiovascular risk factors, particularly insulin resistance, rather than to the presence of PCOS and hyperandrogenaemia per se. However, given the inferential nature of the evidence to date, more rigorous cohort studies of long-term cardiovascular outcomes and clinical trials of risk factor modification are required in women with PCOS.

Revue / Journal Title

Atherosclerosis   ISSN 0021-9150 

Source / Source

2006, vol. 185, n^o2, pp. 227-239 [13 page(s) (article)] (93 ref.)

Langue / Language

Anglais

Editeur / Publisher

Elsevier, Amsterdam, PAYS-BAS  (1970) (Revue)

Mots-clés anglais / English Keywords

Blood vessel ; Circulatory system ; Nutrition disorder ; Pancreatic hormone ; Metabolic diseases ; Endocrinopathy ; Female sterility ; Cyst ; Benign neoplasm ; Ovarian diseases ; Female genital diseases ; Vascular disease ; Cardiovascular disease ; Lipids ; Nutritional status ; Prognosis ; Cohort study ; Risk factor ; Stiffness ; Carotid ; Coronary artery ; Echocardiography ; Incidence ; Insulin ; Human ; Type 2 diabetes ; Dyslipemia ; Obesity ; X Syndrome ; Hyperandrogenism ; Polycystic ovary ; Atherosclerosis ; Cardiovascular disease ;

Mots-clés français / French Keywords

Vaisseau sanguin ; Appareil circulatoire ; Trouble nutrition ; Hormone pancréatique ; Métabolisme pathologie ; Endocrinopathie ; Stérilité femelle ; Kyste ; Tumeur bénigne ; Ovaire pathologie ; Appareil génital femelle pathologie ; Vaisseau sanguin pathologie ; Maladie cardiovasculaire ; Lipide ; Etat nutritionnel ; Pronostic ; Etude cohorte ; Facteur risque ; Rigidité ; Carotide ; Artère coronaire ; Echocardiographie ; Incidence ; Insuline ; Homme ; Diabète type 2 ; Dyslipémie ; Obésité ; X Syndrome ; Hyperandrogénie ; Ovaire polykystique ; Athérosclérose ; Appareil circulatoire pathologie ;

Mots-clés espagnols / Spanish Keywords

Vaso sanguíneo ; Aparato circulatorio ; Trastorno nutricíon ; Hormona pancreática ; Metabolismo patología ; Endocrinopatía ; Esterilidad femenina ; Quiste ; Tumor benigno ; Ovario patología ; Aparato genital hembra patología ; Vaso sanguíneo patología ; Cardiovascular enfermedad ; Lípido ; Estado nutricional ; Pronóstico ; Estudio cohorte ; Factor riesgo ; Rigidez ; Carótida ; Arteria coronaria ; Ecocardiografía ; Incidencia ; Insulina ; Hombre ; Diabetes de tipo 2 ; Dislipemia ; Obesidad ; X Síndrome ; Hiperandrogenismo ; Ovario poliquístico ; Ateroesclerosis ; Aparato circulatorio patología ;

Mots-clés d'auteur / Author Keywords

Polycystic ovary syndrome ; Cardiovascular function and structure ; Cardiovascular risk ; Insulin resistance ;

Localisation / Location

INIST-CNRS, Cote INIST : 1713, 35400013308003.0020