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Titre du document / Document title

Therapeutic effect of a traditional Chinese medicine, ren-shen-yang-rong-tang (Japanese name: Ninjin'yoeito) on nitric oxide-mediated lung injury in a mouse infected with murine cytomegalovirus

Auteur(s) / Author(s)

TANAKA Kazuo (1) ; SAWAMURA Sadaaki (1) ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

(1) Laboratory of Infections Diseases, Tokai University School of Medicine, Bohseidai, Isehara, Kanagawa 259-1193, JAPON

Résumé / Abstract

The therapeutic effect of a traditional Chinese medicine ren-shen-yang-rong-tang (Japanese name: Ninjin'yoeito, NYT) on murine cytomegalovirus (MCMV)-associated pneumonitis was examined. In MCMV-pneumonitis, IFN-γ-induced nitric oxide (NO) mediates its pathogenesis. When mice, which had been infected with 0.2LD50 of MCMV at 28 days previously, were intraperitoneally injected with anti-CD3 monoclonal antibody (mAb), MCMV-pneumonitis was induced in the lung, where high amounts of IFN-γ-producing cells thereafter accumulated, accompanied by an elevation in the NO level in the serum and abundant expression of inducible NO synthase (iNOS) mRNA, thus resulting in all mice eventually dying. When the mice were orally treated with NYT (1000 mg/kg/day) once on the day of mAb injection and once the day after, the expression level of iNOS-mRNA was suppressed and NO level in the serum decreased. The survival rate improved from 0% to 57.1%. The pathological findings of the lungs in the NYT-treated mice were comparable to those of the uninfected controls. In contrast, NYT itself did not affect either the ratio of IFN-γ-producing cells or MCMV titer. As a result, NYT had a therapeutic effect on MCMV-pneumonitis by decreasing the degree of inflammation mediated by the IFN-γ-induced NO. It is also interesting to note that only two oral administrations of NYT had a therapeutic effect on viral disease.

Revue / Journal Title

International immunopharmacology    ISSN  1567-5769 

Source / Source

2006, vol. 6, no4, pp. 678-685 [8 page(s) (article)] (21 ref.)

Langue / Language

Anglais

Editeur / Publisher

Elsevier, Kidlington, ROYAUME-UNI  (2001) (Revue)

Mots-clés anglais / English Keywords

Respiratory system

;

Virus

;

Herpesviridae

;

Betaherpesvirinae

;

Vertebrata

;

Mammalia

;

Rodentia

;

Asia

;

Radical scavenger

;

Antioxidant

;

Viral disease

;

Murine cytomegalovirus

;

Infection

;

Mouse

;

Animal

;

Lesion

;

Injury

;

Lung

;

Nitric oxide

;

Japan

;

Japanese

;

Chinese medicine

;

Folk medicine

;

Treatment

;

Mots-clés français / French Keywords

Appareil respiratoire

;

Virus

;

Herpesviridae

;

Betaherpesvirinae

;

Vertebrata

;

Mammalia

;

Rodentia

;

Asie

;

Intercepteur radical

;

Antioxydant

;

Virose

;

Cytomegalovirus murin

;

Infection

;

Souris

;

Animal

;

Lésion

;

Blessure

;

Poumon

;

Azote monoxyde

;

Japon

;

Japonais

;

Médecine chinoise

;

Médecine traditionnelle

;

Traitement

;

Mots-clés espagnols / Spanish Keywords

Aparato respiratorio

;

Virus

;

Herpesviridae

;

Betaherpesvirinae

;

Vertebrata

;

Mammalia

;

Rodentia

;

Asia

;

Interceptor radical

;

Antioxidante

;

Virosis

;

Murine cytomegalovirus

;

Infección

;

Ratón

;

Animal

;

Lesión

;

Herida

;

Pulmón

;

Nitrógeno monóxido

;

Japón

;

Japonés

;

Medicina china

;

Medicina tradicional

;

Tratamiento

;

Mots-clés d'auteur / Author Keywords

Ninjin'yoeito

;

Cytomegalovirus

;

Peumonitis

;

Nitric oxide

;

Radical scavenger

;

Localisation / Location

INIST-CNRS, Cote INIST : 27109, 35400013284907.0190

Nº notice refdoc (ud4) : 17569319



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