Titre du document / Document title

Brain-derived neurotrophic factor and autoantibodies to neural antigens in sera of children with autistic spectrum disorders, landau-kleffner syndrome, and epilepsy

Auteur(s) / Author(s)

CONNOLLY Anne M. ⁽¹⁾ ; CHEZ Michael ⁽²⁾ ; STREIF Elizabeth M. ⁽¹⁾ ; KEELING Richard M. ⁽¹⁾ ; GOLUMBEK Paul T. ⁽¹⁾ ; KWON Jennifer M. ⁽³⁾ ; RIVIELLO James J. ⁽⁴⁾ ; ROBINSON Ricki G. ⁽⁵⁾ ; NEUMAN Rosalind J. ⁽⁶⁾ ; DEUEL Ruth Mary K. ⁽⁷⁾ ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ Department of Neurology and Pediatrics, Washington University School of Medicine, St. Louis, Missouri, ETATS-UNIS
⁽²⁾ Department of Neurology, Rosalind Franklin University, Chicago Medical School, Chicago, Illinois, ETATS-UNIS
⁽³⁾ Harvard Medical School, Boston, Massachusetts, ETATS-UNIS
⁽⁴⁾ University of Rochester, Rochester, New York, ETATS-UNIS
⁽⁵⁾ Keck School of Medicine at USC, Los Angeles, California, ETATS-UNIS
⁽⁶⁾ Department of Psychiatry and Genetics, Washington University School of Medicine, St. Louis, Missouri, ETATS-UNIS
⁽⁷⁾ Saint Louis University, St. Louis, Missouri, ETATS-UNIS

Résumé / Abstract

Background- Brain derived neurotrophic factor (BDNF) elevation in newborn sera predicts intellectual/social developmental abnormalities. Other autoantibodies (AAs) to endothelial cells (ECs) and myelin basic protein (MBP) are also elevated in some children. We tested relationships between BDNF, BDNF AAs, and other AAs in children with these disorders. Methods: BDNF levels and IgG/IgM autoantibodies to BDNF, ECs, MBP, and histories were measured in children with autism. childhood disintegrative disorder (CDD), pervasive developmental delay-not otherwise specified (PDD-nos), acquired epilepsy, Landau-Kleffner syndrome (LKS); healthy children (HC), and children with non-neurological illnesses (NNI). Results: Mean BDNF levels were elevated in children with autism and CDD, (p £ 0.0002) compared to HC or NNI. Mean IgG and IgM BDNF AAs were elevated in children with autism, CDD and epilepsy (p ≤ 0.0005) compared to HC but not to NNI. Mean IgM AA EC titers detected by immunocytochemistry were higher in autism, PDD-NOS, epilepsy, and LKS (p ≤ 0.005) compared to HC and NNI. While mean ELISA IgG EC AAs were higher in autism and PPD-NOS (p < 0.005) compared to HC but not NNI, ELISA IgM Ec AAs were higher in children with autism, CDD, PDD-NOS, and epilepsy compared to both HC and NNI (p < 0.0005). Mean anti-MBP IgG and IgM titers were higher in all study groups (p < 0.005) except for LKS compared to both HC and NNI. Conclusion: Children with developmental disorders and epilepsy have higher AAs to several neural antigens compared to controls. The presence of both BDNF AAs and elevated BDNF levels in some children with autism and CDD suggests a previously unrecognized interaction between the immune system and BDNF.

Revue / Journal Title

Biological psychiatry   ISSN 0006-3223   CODEN BIPCBF 

Source / Source

2006, vol. 59, n^o4, pp. 354-363 [10 page(s) (article)] (62 ref.)

Langue / Language

Anglais

Editeur / Publisher

Elsevier Science, New York, NY, ETATS-UNIS  (1969) (Revue)

Mots-clés anglais / English Keywords

Central nervous system disease ; Cerebral disorder ; Nervous system diseases ; Developmental disorder ; Human ; Child ; Epilepsy ; Landau Kleffner syndrome ; Autism ; Autoimmunity ; Brain derived neurotrophic factor ;

Mots-clés français / French Keywords

Système nerveux central pathologie ; Encéphale pathologie ; Système nerveux pathologie ; Trouble développement ; Homme ; Enfant ; Epilepsie ; Landau Kleffner syndrome ; Autisme ; Autoimmunité ; Facteur BDNF ;

Mots-clés espagnols / Spanish Keywords

Sistema nervosio central patología ; Encéfalo patología ; Sistema nervioso patología ; Trastorno desarrollo ; Hombre ; Niño ; Epilepsia ; Landau Kleffner síndrome ; Autismo ; Autoinmunidad ; Factor BDNF ;

Mots-clés d'auteur / Author Keywords

Antiendothelial antibodies ; autoantibodies ; antinuclear antibodies ; Landau-Kleffner syndrome ; autistic spectrum disorder ;

Localisation / Location

INIST-CNRS, Cote INIST : 11378, 35400015340525.0090