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Titre du document / Document title

Clinical studies on the anti-irritation effects of mung bean (Phaseolus aureus) extract in cosmetics

Auteur(s) / Author(s)

JO B.-K. (1) ; AHN G.-W. (2) ; JEONG J.-H. (2) ; HWANG Y.-Il. (1) ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

(1) Division of Food Science and Biotechnology Kyungnam University, Masan 631-701, COREE, REPUBLIQUE DE
(2) R&D center Coreana Cosmetics Co. Ltd, Cheonan 330-833, COREE, REPUBLIQUE DE

Résumé / Abstract

The aim of this study is to assess the anti-irritation activities of mung bean (Phaseolus aureus) extract against various irritants used in cosmetics. For its antidotal activity, mung bean has been used as a medicinal or cosmetic material since ancient times. However, there have been few reports describing the biological activities of these beans and no comprehensive surveys of the constituents. An ethanolic extract of mung bean was obtained and the major constituents, such as vitexin and isovitexin, were isolated. It was previously reported that the mung bean extract containing vitexin and isovitexin had excellent antioxidant and anti-inflammatory activities. To investigate the mechanisms of anti-inflammatory activity of mung bean extract, the inhibitory effects on histamine release from rat peritoneal mast cells and lipoxygenase activity were examined. Mung bean extract inhibited histamine release in a concentration dependent manner but showed no inhibitory activity in the 5-lipoxygenase assay. And, clinical studies were conducted to evaluate the anti-irritation effects of mung bean extract against various irritants used in cosmetics such as lactic acid, retinol, and preservatives. When 2.0% of mung bean extract was applied to cosmetic formulae containing each of irritants, it revealed considerable anti-irritation efficacy. Results of a human patch test with 20 volunteers showed that this extract reduced skin irritations caused by 5.0% lactic acid, 4000 ID retinol, and 1.0% preservative mixture by about 60%, 30%, and 50% respectively. The stinging potential test for assessing subjective irritation also showed that the extract reduced the unpleasant sensations by about 50-30%. Finally, a double blind usage test with 30 subjects was performed to compare formulae containing mung bean extract with placebo. From the results of questionnaires for 4 weeks of use, the excellent anti-irritation effect of mung bean extract was confirmed. Conclusively, new material could be discovered that had anti-irritation effects and this mung bean extract could be applied to the final cosmetic products successfully.

Revue / Journal Title

SÖFW-Journal    ISSN  0942-7694 

Source / Source

2006, vol. 132, no1-2, [Note(s): 8-16 [7 p.]] (16 ref.)

Langue / Language

Anglais
Revue : Allemand

Editeur / Publisher

Verlag für chemische Industrie, Augsburg, ALLEMAGNE  (1992) (Revue)

Mots-clés anglais / English Keywords

Vegetable crop

;

Spermatophyta

;

Angiospermae

;

Dicotyledones

;

Leguminosae

;

Neurotransmitter

;

Flavone derivatives

;

C-Glycoside

;

Toxicity

;

Human

;

Clinical test

;

Mast cell

;

Histamine

;

Prevention

;

Antidote

;

Plant origin

;

Extract

;

Cosmetic

;

Vigna radiata

;

Irritation

;

Mots-clés français / French Keywords

Plante légumière

;

Spermatophyta

;

Angiospermae

;

Dicotyledones

;

Leguminosae

;

Histocyte

;

Isovitexine

;

Vitexine

;

Neurotransmetteur

;

Flavone dérivé

;

C-Glycoside

;

Toxicité

;

Homme

;

Test clinique

;

Mastocyte

;

Histamine

;

Prévention

;

Antidote

;

Origine végétale

;

Extrait

;

Cosmétique

;

Vigna radiata

;

Irritation

;

Mots-clés espagnols / Spanish Keywords

Hortalizas (plantas)

;

Spermatophyta

;

Angiospermae

;

Dicotyledones

;

Leguminosae

;

Neurotransmisor

;

Flavona derivado

;

C-Glicósido

;

Toxicidad

;

Hombre

;

Prueba clínica

;

Mastocito

;

Histamina

;

Prevención

;

Antídoto

;

Origen vegetal

;

Extracto

;

Cosmético

;

Vigna radiata

;

Irritación

;

Localisation / Location

INIST-CNRS, Cote INIST : 5380, 35400013574224.0020

Nº notice refdoc (ud4) : 17542470



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