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Titre du document / Document title

Motherhood and the hormones of pregnancy modify concentrations of hippocampal neuronal dendritic spines

Auteur(s) / Author(s)

KINSLEY Craig H. (1) ; TRAINER Regina (1) ; STAFISSO-SANDOZ Graciela (1) ; QUADROS Princy (1) ; MARCUS Lori Keyser (1) ; HEARON Christa (1) ; MEYER Elizabeth Ann Amory (1) ; HESTER Naomi (1) ; MORGAN Melissa (1) ; KOZUB Frederick J. (1) ; LAMBERT Kelly G. (2) ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

(1) Department of Psychology-Center for Neuroscience, 103 Richmond Hall, University of Richmond, VA 23173, ETATS-UNIS
(2) Department of Psychology, Randolph-Macon College, Ashland, VA 23005, ETATS-UNIS

Résumé / Abstract

Short-term fluctuations in steroid hormones such as estradiol (E2) and progesterone (P) can affect the concentration of hippocampal dendritic spines in adult, cycling nulliparous female rats. Pregnancy is characterized by a significantly longer duration of substantially elevated E2 and P compared to the estrous cycle. Thus, even greater changes than those reported during estrus may be evident. In two experiments, we examined the extent to which reproductive and hormonal state altered the concentration of apical neuronal dendritic spines of the CA1 region of the hippocampus in the following age-matched groups (N's = 7-10/group) of rats: in Exp. 1., CA1 dendritic spine density was examined in nulliparous diestrus (DES), proestrus (PRO), and estrus (ES) females, and late-pregnant (LP) (day 21) and lactating (day 5-6; LACT) females. In Exp. 2, the effects on spine density of a regimen mimicking pregnancy (and that stimulates maternal behavior) were examined, using ovariectomized, no hormone-exposed (OVX-minus) vs. sequential P&E2-treated (OVX + P&E2) groups. For both experiments, brains were removed, Golgi-Cox-stained and the most lateral tertiary branches of the apical dendrite of completely-stained hippocampal CA1 pyramidal neurons were traced with oil-immersion at x 1600 and dendritic spine density (# spines/10 μ dendritic segment) recorded. In Exp. 1, spine density was increased in LP and LACT females (which were not different) compared to the other virgin groups, including PRO females, who had more spines than DES and ES. In Exp. 2, OVX + P&E2 displayed significantly more dendritic spines per 10 μ than OVX-minus females (and had numbers that were similar to those of LP and LACT from Exp. 1). Pregnancy and its attendant hormonal fluctuations, therefore, may alter hippocampal neurons that regulate some non-pup-directed components of maternal behavior (e.g., nest building) or behaviors that support maternal behavior (e.g., foraging, associative memory).

Revue / Journal Title

Hormones and behavior    ISSN  0018-506X   CODEN HOBEAO 

Source / Source

2006, vol. 49, no2, pp. 131-142 [12 page(s) (article)] (2 p.1/4)

Langue / Language

Anglais

Editeur / Publisher

Elsevier, Amsterdam, PAYS-BAS  (1969) (Revue)

Mots-clés anglais / English Keywords

Central nervous system

;

Encephalon

;

Vertebrata

;

Mammalia

;

Rodentia

;

Rat

;

Animal

;

Dendritic spine

;

Hippocampus

;

Pregnancy

;

Hormone

;

Mots-clés français / French Keywords

Système nerveux central

;

Encéphale

;

Vertebrata

;

Mammalia

;

Rodentia

;

Rat Sprague-Dawley

;

Rat

;

Animal

;

Epine dendritique

;

Hippocampe

;

Gestation

;

Hormone

;

Mots-clés espagnols / Spanish Keywords

Sistema nervioso central

;

Encéfalo

;

Vertebrata

;

Mammalia

;

Rodentia

;

Rata

;

Animal

;

Espina dendrítica

;

Hipocampo

;

Gestación

;

Hormona

;

Mots-clés d'auteur / Author Keywords

Pregnancy

;

Estradiol

;

Progesterone

;

Localisation / Location

INIST-CNRS, Cote INIST : 14364, 35400011518538.0020

Nº notice refdoc (ud4) : 17537037



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