Titre du document / Document title

The PPAR-γ agonist pioglitazone post-transcriptionally induces p21 in PC3 prostate cancer but not in other cell lines

Auteur(s) / Author(s)

RADHAKRISHNAN Senthil K. ; GARTEL Andrei L. ;

Résumé / Abstract

The anti-diabetic thiozolidinedione compound pioglitazone, a peroxisome proliferator-activated receptor-γ (PPAR-γ) agonist, has been found to have growth inhibitory effects in some cancer cells. The mechanism underlying this growth suppression is not well understood. In this study, we evaluated the effect of pioglitazone on p53 and p21 expression in various cancer cell lines with different p53 status. The cells with wild type p53 did not show any change in p53 levels in response to pioglitazone. Also, none of the cell lines exhibited p53-dependent or independent transcriptional induction of p21^WAF1/CIP1 by pioglitazone. However, PC3, an androgen-insensitive prostate cancer cell line with deletion of p53 showed an appreciable post-transcriptional induction of p21 expression after treatment with pioglitazone. These results imply that pioglitazone generally does not modulate p21 transcription in human cancer cell lines.

Revue / Journal Title

Cell cycle   ISSN 1538-4101 

Source / Source

2005, vol. 4, n^o4, pp. 582-584 [3 page(s) (article)]

Langue / Language

Anglais

Editeur / Publisher

Landes Bioscience, Georgetown, TX, ETATS-UNIS  (2002) (Revue)

Mots-clés d'auteur / Author Keywords

p53 ; p21 ; pioglitazone ; PPAR-y ; PC3 ;

Localisation / Location

INIST-CNRS, Cote INIST : 27667, 35400013312765.0200