Titre du document / Document title

Azathioprine myelosuppression in multiple sclerosis : characterizing thiopurine methyltransferase polymorphisms

Auteur(s) / Author(s)

FROHRNAN E. M. ^{(1 2)} ; HAVRDOVA E. ⁽³⁾ ; LEVINSON B. ⁽⁴⁾ ; SLANAR O. ⁽⁵⁾ ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ Department of Neurology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX, ETATS-UNIS
⁽²⁾ Department of Ophthalmology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX, ETATS-UNIS
⁽³⁾ Department of Neurology, Charles University, Prague, TCHEQUE, REPUBLIQUE
⁽⁴⁾ Department of Hematology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX, ETATS-UNIS
⁽⁵⁾ Department of Clinical Pharmacology, Charles University, Prague, TCHEQUE, REPUBLIQUE

Résumé / Abstract

We describe two multiple sclerosis patients who developed pancytopenia following treatment with azathioprine. They were found to have the homozygous polymorphism for thiopurine methyltransferase deficiency and recovered after cessation of drug therapy. We review the literature concerning this molecular derangement and underscore the importance of performing surveillance testing for allelic characterization prior to treatment intervention with this agent for immune-mediated disorders.

Revue / Journal Title

Multiple sclerosis   ISSN 1352-4585 

Source / Source

2006, vol. 12, n^o1, pp. 108-111 [4 page(s) (article)] (18 ref.)

Langue / Language

Anglais

Editeur / Publisher

Arnold, London, ROYAUME-UNI  (1995) (Revue)

Mots-clés anglais / English Keywords

Hemopathy ; Central nervous system disease ; Inflammatory disease ; Enzyme ; Transferases ; Methyltransferases ; Surveillance ; Homozygosity ; Treatment ; Human ; Polymorphism ; Thiopurine S-methyltransferase ; Azathioprine ; Deficiency ; Pancytopenia ; Multiple sclerosis ; Degenerative disease ; Nervous system diseases ;

Mots-clés français / French Keywords

Hémopathie ; Système nerveux central pathologie ; Maladie inflammatoire ; Enzyme ; Transferases ; Methyltransferases ; Surveillance ; Homozygotie ; Traitement ; Homme ; Polymorphisme ; Thiopurine S-methyltransferase ; Azathioprine ; Déficit ; Pancytopénie ; Sclérose en plaques ; Maladie dégénérative ; Système nerveux pathologie ;

Mots-clés espagnols / Spanish Keywords

Hemopatía ; Sistema nervosio central patología ; Enfermedad inflamatoria ; Enzima ; Transferases ; Methyltransferases ; Vigilancia ; Homocigosis ; Tratamiento ; Hombre ; Polimorfismo ; Thiopurine S-methyltransferase ; Azatioprina ; Déficiencia ; Pancitopenia ; Esclerosis en placa ; Enfermedad degenerativa ; Sistema nervioso patología ;

Mots-clés d'auteur / Author Keywords

azathioprine ; polymorphism ; thiopurine methytransferase ;

Localisation / Location

INIST-CNRS, Cote INIST : 26577, 35400013535886.0150