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Titre du document / Document title

Cholinergic enhancement of episodic memory in healthy young adults

Auteur(s) / Author(s)

GRÖN Georg (1) ; KIRSTEIN Matthias (1) ; THIELSCHER Axel (1) ; RIEPE Matthias W. (2) ; SPITZER Manfred (1 3) ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

(1) Department of Psychiatry, University of Ulm, Leimgrubenweg 12, 89075 Ulm, ALLEMAGNE
(2) Department of Psychiatry Mental Health and Old Age Psychiatry, Charité Medical University, Eschenallee 3, 14050 Berlin, ALLEMAGNE
(3) Transfer Center for Neuroscience and Learning (ZNL), University of Ulm, Beim Alten Fritz 2, 89075 Ulm, ALLEMAGNE

Résumé / Abstract

Rationale: Acetylcholine esterase (AchE) inhibitors are known to remediate symptoms of Alzheimer's disease. However, only few systematic data exist on the effects of cholinergic treatment on cognitive functions in normal subjects. Objective: This study evaluated the effects of donepezil, an inhibitor of AchE, on cognitive performance in young and healthy subjects. Methods: We used a randomised double-blind parallel group placebo-controlled repeated measures design to investigate changes of cognitive functions in a group of 30 young healthy male subjects (mean age 23.9 years±2.24 SD) upon application of donepezil or placebo for 30 days. Attentional and executive functions, visual and verbal short-term and working memory, semantic memory, as well as verbal and visual episodic memory were investigated using an extensive neuropsychological test battery. Results: Time-by-group interactions demonstrated significant drug effects that were specific to episodic memory in both the verbal and visual domain. Additionally, donezepil significantly improved long-term visual episodic recall. In none of the other functions under investigation any significant treatment effects were observed. Conclusion: Given this specific drug effect and the well-known relevance of the hippocampal region for episodic memory, we conclude that this region appears to be the major target of cholinergic enhancement in healthy subjects due to long-term inhibition of AchE.

Revue / Journal Title

Psychopharmacologia    ISSN  0033-3158   CODEN PSYPAG 

Source / Source

2005, vol. 182, no1, pp. 170-179 [10 page(s) (article)] (1 p.1/2)

Langue / Language

Anglais

Editeur / Publisher

Springer, Berlin, ALLEMAGNE  (1959) (Revue)

Mots-clés anglais / English Keywords

Central nervous system

;

Encephalon

;

Enzyme

;

Hydrolases

;

Esterases

;

Carboxylic ester hydrolases

;

Human

;

Hippocampus

;

Acquisition process

;

Learning

;

Attention

;

Acetylcholinesterase

;

Young adult

;

Cognition

;

Episodic memory

;

Mots-clés français / French Keywords

Système nerveux central

;

Encéphale

;

Enzyme

;

Hydrolases

;

Esterases

;

Carboxylic ester hydrolases

;

Homme

;

Hippocampe

;

Processus acquisition

;

Apprentissage

;

Attention

;

Acetylcholinesterase

;

Adulte jeune

;

Cognition

;

Mémoire épisodique

;

Mots-clés espagnols / Spanish Keywords

Sistema nervioso central

;

Encéfalo

;

Enzima

;

Hydrolases

;

Esterases

;

Carboxylic ester hydrolases

;

Hombre

;

Hipocampo

;

Proceso adquisición

;

Aprendizaje

;

Atención

;

Acetylcholinesterase

;

Adulto joven

;

Cognición

;

Memoria episódica

;

Mots-clés d'auteur / Author Keywords

Acetylcholinesterase

;

Attention

;

Cognition

;

Learning and memory

;

Hippocampus

;

Human

;

Localisation / Location

INIST-CNRS, Cote INIST : 1761, 35400013474318.0190

Nº notice refdoc (ud4) : 17433127



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