Titre du document / Document title

Increased prevalence of antithyroid antibodies and subclinical hypothyroidism in children with juvenile idiopathic arthritis

Auteur(s) / Author(s)

HAREL Liora ; PRAIS Dario ; UZIEL Yosef ; MUKAMEL Masza ; HASHKES Philip ; HAREL Gideon ; AMIR Jacob ; MONSELISE Yehudit ; PRESS Joseph ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, ISRAEL
Department of Pediatrics C and the Rheumatology Unit, Schneider Children 's Medical Center of Israel, ISRAEL
Endocrinology Unit, Rabin Medical Center, Golda Campus, ISRAEL
Laboratory of Clinical Immunology, Rabin Medical Center, Beilinson Campus, Petah Tiqva, ISRAEL
Emergency Department, Soroka Medical Center, Beer Sheva, ISRAEL
Department of Pediatrics, Sapir Medical Center, Kfar Saba, ISRAEL
Department of Rheumatic Diseases, Cleveland Clinic Foundation, Cleveland, Ohio, ETATS-UNIS

Résumé / Abstract

Objective. To estimate the occurrence of antithyroid antibodies (ATA) and hypothyroidism in children with juvenile idiopathic arthritis (JIA) compared to matched healthy controls. Methods. The occurrence of ATA, including antithyroglobulin (anti-TG) and antithyroid peroxidase (anti-TPO) antibodies, was evaluated by quantitative immunometric ELISA in children with JIA and in a healthy matched control group. Thyroid function was assessed in both groups. Results. The study group included 66 patients with JIA (50 girls, 16 boys) of mean age 11.7 ± 4.4 years (range 2-23). The control group included 89 children (71 girls, 18 boys) of mean age 10.8 ± 4.2 years (range 2-18). Mean age at onset of joint disease was 7.3 ± 3.6 years (range 1-15). Anti-TG antibodies were found in 7 of 62 patients (11.3%) in the JIA group and 2 of 89 controls (2.2%) (p = 0.03); anti-TPO antibodies were found in 5 of 65 patients (7.9%) and one of 89 controls (1.1%) (p = 0.08). All patients with ATA had oligoarticular type JIA (p = 0.01). Mean thyroid stimulating hormone (TSH) levels were higher in the study group than in controls (2.6 ± 2.3 vs 1.9 ± 1.0 mIU/l; p = 0.01); levels were above normal range (0.4-4 mIU/1) in 8 study patients (12%) and 3 controls (3.4%) (p = 0.055). Overall, ATA were found in 9 of the 150 study participants, 4 (44%) of whom had TSH levels above 4 mIU/l (p = 0.001). Conclusion. Children with JIA have a higher than normal incidence of ATA and subclinical hypothyroidism and should be routinely screened for these variables.

Revue / Journal Title

Journal of rheumatology   ISSN 0315-162X   CODEN JRHUA9 

Source / Source

2006, vol. 33, n^o1, pp. 164-166 [3 page(s) (article)] (15 ref.)

Langue / Language

Anglais

Editeur / Publisher

Journal of Rheumatology Publishing, Toronto, ON, CANADA  (1974) (Revue)

Mots-clés anglais / English Keywords

Diseases of the osteoarticular system ; Inflammatory joint disease ; Thyroid diseases ; Endocrinopathy ; Epidemiology ; Human ; Chronic ; Rheumatology ; Child ; Hypothyroidism ; Antibody ; Prevalence ; Juvenile rheumatoid arthritis ;

Mots-clés français / French Keywords

Système ostéoarticulaire pathologie ; Rhumatisme inflammatoire ; Thyroïde pathologie ; Endocrinopathie ; Epidémiologie ; Homme ; Chronique ; Rhumatologie ; Enfant ; Hypothyroïdie ; Anticorps ; Prévalence ; Arthrite chronique juvénile ;

Mots-clés espagnols / Spanish Keywords

Sistema osteoarticular patología ; Reumatismo inflamatorio ; Tiroides patología ; Endocrinopatía ; Epidemiología ; Hombre ; Crónico ; Reumatología ; Niño ; Hipotiroidismo ; Anticuerpo ; Prevalencia ; Artritis crónica juvenil ;

Localisation / Location

INIST-CNRS, Cote INIST : 16024, 35400013440384.0270