Titre du document / Document title
Analgesic effects of aqueous extracts of the leaves of Bryophyllum pinnatum
Auteur(s) / Author(s)
IGWE S. A. (1) ;
AKUNYILI D. N. (2) ;
Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)
(1) Department of Pharmacology and Therapeutics, College of Health Sciences, Ebonyi State University Teaching Hospital, Abakaliki, NIGERIA
(2) Department of Pharmacology and Therapeutics, College of Medicine, University of Nigeria Teaching Hospital, Enugu, NIGERIA
Résumé / Abstract
Bryophyllum pinnatum Linn (Crassulaceae) is a shrub with simple or trifoliate petiolate leaves used mainly in folk medicine to alleviate pains of various intensities and etiologies. The analgesic potency of the aqueous extract of the leaves of B. pinnatum was investigated using animal models. Results showed that the aqueous extract of B. pinnatum was devoid of severe toxic effects (LD
50 = 660.9 ± 2.65 mg/kg body weight), increased the pain threshold in rats using the hot plate or thermal methods, inhibited or reduced phenylbenzoquinone-induced writhing or abdominal stretches in mice in a dose-dependent manner, and produced a weak or an inferior anti-inflammatory activity than aspirin. It is concluded that the aqueous extract of B. pinnatum can demonstrate strong analgesic potency comparable in a times-and dose-dependent manner to a nonsteroidal anti-inflammatory drug.
Revue / Journal Title
Pharmaceutical biology
ISSN
1388-0209
Source / Source
2005, vol. 43, n
o8, pp. 658-661 [4 page(s) (article)] (11 ref.)
Langue / Language
Anglais
Editeur / Publisher
Swets & Zeitlinger, Lisse, PAYS-BAS
(1998)
(Revue)
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Localisation / Location
INIST-CNRS, Cote INIST : 1635, 35400013483822.0030
Nº notice refdoc (ud4) : 17383370
