Titre du document / Document title

Inflammation and conjugated linoleic acid : mechanisms of action and implications for human health

Auteur(s) / Author(s)

ZULET M. A. ; MARTI A. ; PARRA M. D. ; MARTINEZ J. A. ;

Résumé / Abstract

Data from a number of studies and trials have shown that different conjugated linoleic acids (CLA's) may produce beneficial effects on cancer, atherosclerosis, hypertension, diabetes and changes in body composition. Despite the increasing knowledge about CLA's implications on health, the mechanism of action of these fatty acids is not completely understood. Moreover, human studies indicate that some of these beneficial effects are considerably less evident than anticipated from mice studies, while the efficacy and safety of dietary supplements containing CLA have been questioned in some intervention trials. Recently, it has been suggested that the anti-carcinogenic and anti-atherosclerosis effects of CLA's stem from its antiinflammatory properties. Because inflammatory responses are associated with the pathophysiology of many diseases, including obesity and the metabolic syndrome, the investigation in this area is of growing interest in recent years.

Revue / Journal Title

Journal of physiology and biochemistry   ISSN 1138-7548   CODEN JPBIF2 

Source / Source

2005, vol. 61, n^o3, pp. 483-494 [12 page(s) (article)]

Langue / Language

Anglais

Editeur / Publisher

Universidad de Navarra, Pamplona, ESPAGNE  (1996) (Revue)

Mots-clés d'auteur / Author Keywords

Inflammation ; Oxidative stress ; Obesity ; Metabolic syndrome ; Conjugated linoleic acid ;

Localisation / Location

INIST-CNRS, Cote INIST : 3161, 35400013490280.0070