Titre du document / Document title

Pharmacokinetic/pharmacodynamic modelling of NSAIDs in a model of reversible inflammation in the cat

Auteur(s) / Author(s)

GIRAUDEL Jerome M. ⁽¹⁾ ; DIQUELOU Armelle ⁽¹⁾ ; LAROUTE Valerie ⁽¹⁾ ; LEES Peter ⁽²⁾ ; TOUTAIN Pierre-Louis ⁽¹⁾ ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ UMR 181 de Physiopathologie et Toxicologie Expérimentales INRA/ENVT, Ecole Nationale Vétérinaire de Toulouse, 23 chemin des Capelles, BP 87614, 31076 Toulouse, FRANCE
⁽²⁾ Department of Veterinary Basic Sciences, Royal Veterinary College, Hawkshead Campus, North Mymms, Hatfield, Hertfordshire AL9 7TA, ETATS-UNIS

Résumé / Abstract

1 Data on the relationships between plasma concentration and analgesic and anti-inflammatory effects of NSAIDs are limited because most inflammation models do not permit pharmacokmetic/ pharmacodynamic (PK/PD) modelling to be readily performed. 2 In this study, a kaolin-induced inflammation model in the cat was evaluated for pre-clinical characterization of the pharmacodynamic profiles of NSAIDs (determination of efficacy, potency, sensitivity (that is the slope of the concentration-effect relationship) and duration of drug response), using meloxicam as a probe article. 3 Indirect response PK/PD models described the time course and magnitude of responses produced by 0.3 mg kg meloxicam administered subcutaneously. For endpoints for which spontaneous recovery from inflammation was superimposed on drug response, a PK/PD model with a time-dependent K_in was used to allow for the spontaneous changes of the inflammation with time. 4 The selected endpoints were suitable for studying simultaneously the analgesic, anti-inflammatory and antipyretic effects of meloxicam, allowing comparison of relative potencies for these effects. Mean ±s.d. IC₅₀ or EC₅₀ values (ngml ') were 777±124 (body temperature), 841 ± 187 (locomotion variable), 883±215 (pain score), 911±189 (lameness score) and 1298±449 (skin temperature difference). Corresponding mean times±s.d. of peak responses (h) were 5.6±1.3, 8.6±3.8, 5.2±5.0, 5.6±3.7 and 4.3±2.4, respectively. 5 As the pharmacokinetic profiles of meloxicam in cats and humans are similar, simulations of several dosage regimens in the cat provided a pre-clinical basis, illustrating the value of the cat model for predicting a clinical dose regimen for evaluation in man. The predicted loading doses (mg kg^-1) of meloxicam in the cat producing 70% of the maximum attainable responses were 0.29 (body temperature), 0.32 (lameness score), 0.33 (overall locomotion variable), 0.36 (pain score) and 0.50 (skin temperature difference). The values are similar to or somewhat greater than the clinically recommended doses both in cats (0.3 mg kg^-1) and humans (7.5-15mg, that is, between 0.1 and 0.3 mg kg^-1). 6 These findings indicate the potential value of the cat as a laboratory model, and of a PK/PD modelling approach in assisting NSAID development programs in animals and humans.

Revue / Journal Title

British journal of pharmacology   ISSN 0007-1188   CODEN BJPCBM 

Source / Source

2005, vol. 146, n^o5, pp. 642-653 [12 page(s) (article)] (36 ref.)

Langue / Language

Anglais

Editeur / Publisher

Nature Publishing, Basingstoke, ROYAUME-UNI  (1968) (Revue)

Mots-clés anglais / English Keywords

Enzyme ; Oxidoreductases ; Prostaglandin-endoperoxide synthase ; Oxicam derivatives ; Enzyme inhibitor ; Cyclooxygenase 2 inhibitor ; Vertebrata ; Mammalia ; Carnivora ; Fissipedia ; Analgesic ; Meloxicam ; Cat ; Animal ; Inflammation ; Models ; Non steroidal antiinflammatory agent ; Pharmacokinetic pharmacodynamic relationship ;

Mots-clés français / French Keywords

Benzothiazine dérivé ; Enzyme ; Oxidoreductases ; Prostaglandin-endoperoxide synthase ; Oxicam dérivé ; Inhibiteur enzyme ; Inhibiteur cyclooxygenase 2 ; Vertebrata ; Mammalia ; Carnivora ; Fissipedia ; Analgésique ; Méloxicam ; Chat ; Animal ; Inflammation ; Modèle ; Antiinflammatoire non stéroïde ; Relation pharmacocinétique pharmacodynamie ;

Mots-clés espagnols / Spanish Keywords

Enzima ; Oxidoreductases ; Prostaglandin-endoperoxide synthase ; Oxicam derivado ; Inhibidor enzima ; Inhibidor cyclooxygenase 2 ; Vertebrata ; Mammalia ; Carnivora ; Fissipedia ; Analgésico ; Meloxicam ; Gato ; Animal ; Inflamación ; Modelo ; Antiinflamatorio no esteroide ; Relación farmacocinética farmacodinamia ;

Mots-clés d'auteur / Author Keywords

PK/PD modelling ; NSAID ; cat ; reversible inflammation ; meloxicam ; kaolin ;

Localisation / Location

INIST-CNRS, Cote INIST : 4509, 35400013565263.0030