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Titre du document / Document title

Relationship between serum insulin-like growth factor-1 levels and Alzheimer's disease and vascular dementia

Auteur(s) / Author(s)

WATANABE Takuya (1) ; MIYAZAKI Akira (1) ; KATAGIRI Takashi (2) ; YAMAMOTO Hideki (3) ; IDEI Tsunenori (4) ; IGUCHI Takashi (4) ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

(1) Department of Biochemistry, Shown University School of Medicine, Tokyo, JAPON
(2) Third Department of Internal Medicine, Shown University School of Medicine, Tokyo, JAPON
(3) Department of Neuropsychiatry, Shown University School of Medicine, Tokyo, JAPON
(4) Department of Psychiatry, Showa University Karasuyama Hospital, Tokyo, JAPON

Résumé / Abstract

OBJECTIVES: To determine whether decreased serum insulin-like growth factor-1 (IGF-1) levels could be a risk factor for dementia in older people. DESIGN: Case control study. SETTING: Showa University Karasuyama Hospital, Tokyo, Japan. PARTICIPANTS: A total of 436 Japanese elderly subjects: 106 patients with Alzheimer's disease (AD), 103 patients with vascular dementia (VaD), and 227 age-matched controls without dementia. MESUREMENTS: Serum concentrations of IGF-1 and atherogenic lipoproteins, carotid artery intima-media thickness (IMT), and plaques were determined. RESULTS: Mini-Mental State Examination (MMSE) scores were positively correlated with serum IGF-1 concentrations as well as mean blood pressure or body mass index and were negatively correlated with age, serum low-density lipoprotein cholesterol and lipoprotein(a) concentrations, and carotid IMT. Serum IGF-1 concentrations had a significant inverse correlation with carotid IMT. Analysis across the IGF-1 quartiles revealed a threshold effect of low IGF-1 on MMSE score in subjects with the IGF-1 levels of 140 ng/mL or less (50% percentile) versus those with IGF-1 levels greater than 140 ng/mL. Multiple logistic regression concerning AD and VaD retained serum IGF-1 concentrations of 140ng/mL or less and carotid IMT of 0.9mm or more. Patients with AD and VaD had significantly lower IGF-1 concentrations and greater mean IMT than nondemented controls. CONCLUSION: These results suggest that decreased serum IGF-1 level and the progression of carotid atherosclerosis could play a role as independent risk factors for dementia.

Revue / Journal Title

Journal of the American Geriatrics Society    ISSN  0002-8614 

Source / Source

2005, vol. 53, no10, pp. 1748-1753 [6 page(s) (article)] (30 ref.)

Langue / Language

Anglais

Editeur / Publisher

Wiley-Blackwell, Hoboken, NJ, ETATS-UNIS  (1953) (Revue)

Mots-clés anglais / English Keywords

Cardiovascular disease

;

Nervous system diseases

;

Central nervous system disease

;

Degenerative disease

;

Cerebral disorder

;

Human

;

Gerontology

;

Elderly

;

Geriatrics

;

Examination

;

Psychometrics

;

Neuropsychological test

;

Mini Mental State Examination Folstein et al

;

Thickness

;

Vascular wall

;

Vascular disease

;

Vascular dementia

;

Insulin like growth factor 1

;

Serum factor

;

Alzheimer disease

;

Mots-clés français / French Keywords

Appareil circulatoire pathologie

;

Système nerveux pathologie

;

Système nerveux central pathologie

;

Maladie dégénérative

;

Encéphale pathologie

;

Homme

;

Gérontologie

;

Personne âgée

;

Gériatrie

;

Contrôle connaissance

;

Psychométrie

;

Test neuropsychologique

;

Mini Mental State Examination Folstein et al

;

Epaisseur

;

Paroi vasculaire

;

Vaisseau sanguin pathologie

;

Démence vasculaire

;

Facteur croissance IGF1

;

Facteur sérique

;

Démence Alzheimer

;

Mots-clés espagnols / Spanish Keywords

Aparato circulatorio patología

;

Sistema nervioso patología

;

Sistema nervosio central patología

;

Enfermedad degenerativa

;

Encéfalo patología

;

Hombre

;

Gerontología

;

Anciano

;

Geriatría

;

Control conocimientos

;

Psicometría

;

Prueba neuropsichologica

;

Mini Mental State Examination Folstein et al

;

Espesor

;

Pared vascular

;

Vaso sanguíneo patología

;

Demencia vascular

;

Factor crecimiento IGF1

;

Factor sérico

;

Demencia Alzheimer

;

Mots-clés d'auteur / Author Keywords

Alzheimer's disease

;

insulin-like growth factor-1

;

intima-media thickness

;

Mini-Mental State Examination

;

vascular dementia

;

Localisation / Location

INIST-CNRS, Cote INIST : 8328, 35400013192035.0140

Nº notice refdoc (ud4) : 17213585



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