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Titre du document / Document title

Focused electric field across the voltage sensor of potassium channels

Auteur(s) / Author(s)

AHERN Christopher A. ; HORN Richard ;

Résumé / Abstract

Voltage-gated ion channels respond to changes in membrane potential by movement of their voltage sensors across the electric field between cytoplasmic and extracellular solutions. The principal voltage sensors in these proteins are positively charged S4 segments. The absolute magnitude of S4 movement discriminates two competing classes of gating models. In one class, the movement is <10 Å due to the fact that the electric field is focused by aqueous crevices in the channel protein. In an alternative model, based in part on the crystal structure of a potassium channel, the side chains of S4 arginines move their charges across the bilayer's electric field, a distance of >25 Å. Here, using tethered charges attached to an S4 segment, we provide evidence that the electric field falls across a distance of <4 Å, supporting a model in which the relative movement between S4 and the electric field is very small.

Revue / Journal Title

Neuron    ISSN  0896-6273   CODEN NERNET 

Source / Source

2005, vol. 48, no1, pp. 25-29 [5 page(s) (article)]

Langue / Language


Editeur / Publisher

Cell Press, Cambridge, MA, ETATS-UNIS  (1988) (Revue)

Localisation / Location

INIST-CNRS, Cote INIST : 22116, 35400013561502.0070

Nº notice refdoc (ud4) : 17197997

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