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Titre du document / Document title

The prevalence of prostate carcinoma and its precursor in Hungary : An autopsy study

Auteur(s) / Author(s)

SOOS Gyorgyike (1) ; TSAKIRIS Ioannis (1 2) ; SZANTO Janos (2) ; TURZO Csaba (1) ; HAAS P. Gabriel (3) ; DEZSO Balazs (1) ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

(1) Department of Pathology, University of Debrecen, Medical and Health Science Centre, Debrecen, HONGRIE
(2) Department of Oncology, University of Debrecen, Medical and Health Science Centre, Debrecen, HONGRIE
(3) Department of Urology, State University of New York Upstate Medical University, Syracuse, NY 13210, ETATS-UNIS

Résumé / Abstract

Objectives: The prevalence of incidental prostatic adenocarcinoma (PCa) and its precursor, high grade intraepithelial neoplasia (HGPIN) in an autopsy series from Hungarians (Central European Caucasians) was assessed and compared to similar data from the United States and European countries. Methods: Autopsy cases (n = 139; 18-95 years) with no history of urological disease were histologically examined for prostate cancer and HGPIN. After en block removal, the prostate glands were fixed in formalin, sectioned at 3-5 mm intervals and embedded in paraffin. Whole-mount serial sections were stained with Hematoxylin-eosin and examined for the presence of PCa and HGPIN. The frequency of PCa and HGPIN was compared to autopsy data obtained from other geographical areas. Results: We found a 38.8% prevalence of incidental PCa with increasing age-related incidence. Both PCa and HGPIN are first detected in the 3rd decade and show a steady increase with age with respect to number of foci, tumor grade and volume. In the age group 81-95, 86.6% and 60% of men had PCa and HGPIN, respectively. Conclusions: Incidental PCa and HGPIN are very prevalent in Hungarian population, comparable with the high US and the Scandinavian epidemiological data for Caucasians.

Revue / Journal Title

European urology    ISSN  0302-2838   CODEN EUURAV 

Source / Source

2005, vol. 48, no5, pp. 739-744 [6 page(s) (article)] (42 ref.)

Langue / Language

Anglais

Editeur / Publisher

Elsevier, Kidlington, ROYAUME-UNI  (1975) (Revue)

Mots-clés anglais / English Keywords

Prostate disease

;

Malignant tumor

;

Urinary system disease

;

Male genital diseases

;

Europe

;

Nephrology

;

Urology

;

Male

;

Caucasoid

;

Histology

;

Autopsy

;

Hungary

;

Precursor

;

Epidemiology

;

Prevalence

;

Prostate carcinoma

;

Mots-clés français / French Keywords

Prostate pathologie

;

Tumeur maligne

;

Appareil urinaire pathologie

;

Appareil génital mâle pathologie

;

Europe

;

Néphrologie

;

Urologie

;

Mâle

;

Caucasoïde

;

Histologie

;

Autopsie

;

Hongrie

;

Précurseur

;

Epidémiologie

;

Prévalence

;

Carcinome prostate

;

Mots-clés espagnols / Spanish Keywords

Prostata patología

;

Tumor maligno

;

Aparato urinario patología

;

Aparato genital macho patología

;

Europa

;

Nefrología

;

Urología

;

Macho

;

Caucásico

;

Histología

;

Autopsia

;

Hungría

;

Precursor

;

Epidemiología

;

Prevalencia

;

Carcinoma próstata

;

Mots-clés d'auteur / Author Keywords

Incidental prostate carcinoma

;

Epidemiology

;

Autopsy

;

HGPIN

;

Histology

;

Hungary

;

Central European Caucasian males

;

Localisation / Location

INIST-CNRS, Cote INIST : 16847, 35400013561197.0050

Nº notice refdoc (ud4) : 17196128



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