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Titre du document / Document title

Increase in hippocampal cell death after treatment with kainate in zinc deficiency

Auteur(s) / Author(s)

TAKEDA Atsushi (1) ; TAMANO Haruna (1) ; NAGAYOSHI Akito (1) ; YAMADA Kohei (1) ; OKU Naoto (1) ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

(1) Department of Medical Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Shizuoka 422-8526, JAPON

Résumé / Abstract

Susceptibility to kainate-induced seizures is enhanced by zinc deficiency. To evaluate kainate-induced excitotoxicity in zinc deficiency, the relationship between kainate-induced seizures and hippocampal cell death was examined in control and zinc-deficient mice. Mice were fed a control and zinc-deficient diet for 4 weeks, and then intraperitoneally injected with 12 mg/kg kainate every 60 min three times. The rate of dead mice to the total mice was higher in zinc-deficient group than in control group 3 days after the last injection of kainate. In the survivals, which exhibited tonic convulsions in both control and zinc-deficient groups, kainate-induced hippocampal cell death was also analyzed by cresyl violet staining. Neuronal loss was more observed in the CA1, CA2 and CA3 pyramidal cell layers of zinc-deficient group than those of the control group. TUNEL-positive cells were significantly more detected in the CA1 and CA3 pyramidal cell layers of zinc-deficient group. These results demonstrate that kainate-induced hippocampal cell death occurs more easily in zinc deficiency. Extracellular zinc concentration detected with ZnAF-2 was significantly decreased in the hippocampal CA3 of zinc-deficient mice, in agreement with the previous data measured by in vivo microdialsysis. Synaptically released zinc may be less involved in kainate-induced hippocampal cell death in zinc deficiency.

Revue / Journal Title

Neurochemistry international    ISSN  0197-0186   CODEN NEUIDS 

Source / Source

2005, vol. 47, no8, pp. 539-544 [6 page(s) (article)] (32 ref.)

Langue / Language

Anglais

Editeur / Publisher

Elsevier, Kidlington, ROYAUME-UNI  (1980) (Revue)

Mots-clés anglais / English Keywords

Neurotransmitter

;

Excitatory aminoacid

;

Central nervous system

;

Encephalon

;

Toxicity

;

Deficiency

;

Excitotoxicity

;

Glutamate

;

Zinc

;

Kainic acid

;

Treatment

;

Cell death

;

Hippocampus

;

Mots-clés français / French Keywords

Neurotransmetteur

;

Aminoacide excitateur

;

Système nerveux central

;

Encéphale

;

Toxicité

;

Déficit

;

Excitotoxicité

;

Glutamate

;

Zinc

;

Acide kaïnique

;

Traitement

;

Mort cellulaire

;

Hippocampe

;

Mots-clés espagnols / Spanish Keywords

Neurotransmisor

;

Aminoácido excitador

;

Sistema nervioso central

;

Encéfalo

;

Toxicidad

;

Déficiencia

;

Exitotoxicidad

;

Glutamato

;

Zinc

;

Acido kaínico

;

Tratamiento

;

Muerte celular

;

Hipocampo

;

Mots-clés d'auteur / Author Keywords

Glutamate

;

Excitotoxicity

;

Zinc deficiency

;

Hippocampus

;

Localisation / Location

INIST-CNRS, Cote INIST : 18809, 35400013201448.0030

Nº notice refdoc (ud4) : 17186550



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