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Titre du document / Document title

A rapid HPLC procedure for analysis of analgesic pharmaceutical mixtures for quality assurance and drug diversion testing

Auteur(s) / Author(s)

WOLF Carl E. (1) ; POKLIS Alphonse (1) ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

(1) Department of Pathology, Virginia Commonwealth University School of Medicine, P.O. Box 980165, Richmond, Virginia 23298-0165, ETATS-UNIS

Résumé / Abstract

A simple high-performance liquid chromatographic (HPLC) method that allows for the rapid identification and quantification of analgesic and anesthetic solutions typically used in surgical procedures or patient controlled analgesia is presented. The separation of bupivacaine, clonidine, fentanyl, hydromorphone, midazolam, and morphine is complete in less than 20 min. The method allows test solutions to be either directly injected or diluted prior to injection into the HPLC system. The method is useful from the standpoint that pharmaceutical preparations are usually submitted with the known drug of interest and expected concentration. The method is also useful for initial screening of solutions submitted that are either unknown or of questionable identity. The method has been successfully applied as part of hospital-based quality control and quality assurance programs to detect not only errors in the preparation of solutions of scheduled drugs, but also to uncover illegal diversion of drugs of abuse by medical personnel.

Revue / Journal Title

Journal of analytical toxicology    ISSN  0146-4760   CODEN JATOD3 

Source / Source

2005, vol. 29, no7, pp. 711-714 [4 page(s) (article)] (5 ref.)

Langue / Language

Anglais

Editeur / Publisher

Preston Publications, Niles, IL, ETATS-UNIS  (1977) (Revue)

Mots-clés anglais / English Keywords

Quantitative analysis

;

Ultraviolet detector

;

Quality control

;

Narcotic analgesic

;

Midazolam

;

Opiates

;

Local anesthetic

;

Quality assurance

;

Analgesic

;

Chemical analysis

;

HPLC chromatography

;

Mots-clés français / French Keywords

Analyse quantitative

;

Détecteur UV

;

Contrôle qualité

;

Analgésique narcotique

;

Midazolam

;

Opiacés

;

Anesthésique local

;

Assurance qualité

;

Analgésique

;

Analyse chimique

;

Chromatographie HPLC

;

Mots-clés espagnols / Spanish Keywords

Análisis cuantitativo

;

Detector UV

;

Control calidad

;

Analgésico narcotico

;

Midazolam

;

Opiados

;

Anestésico local

;

Aseguración calidad

;

Analgésico

;

Análisis químico

;

Cromatografía HPLC

;

Localisation / Location

INIST-CNRS, Cote INIST : 17415, 35400013202404.0190

Nº notice refdoc (ud4) : 17183795



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