Titre du document / Document title

Cetirizine dihydrochloride interaction with some diclofenac complexes

Auteur(s) / Author(s)

KENAWI Ihsan M. ⁽¹⁾ ; BARSOUM Barsoum N. ⁽¹⁾ ; YOUSSEF Maha A. ⁽¹⁾ ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ Department of Chemistry, Faculty of Science, Cairo University, Giza, EGYPTE

Résumé / Abstract

IR, ¹H NMR and mass spectrometric studies showed that cetirizine dihydrochloride interacted strongly with diclofenac sodium, even when the latter was metal bound, forming high molecular weight stable adducts. These new formations were unaffected by the possible steric constraints that may exist because of coordination yet did not have the power to break the formed coordinate bonds. The formed ionic bond took place between the carbonyl ion of diclofenac and the positively charged piperazine ring of cetirizine, forming a ternary compound in the case of the divalent metal clusters (Ca{(dic)₂.2H₂O}, Mg{(dic)₂.2H₂O}, Zn{(dic)₂.2H₂O}) and a quaternary one with the trivalent iron cluster (Fe{dic}₃.3H₂O). IR bands assigned to vNH, δNH and νC-N were shifted to lower frequency values in the spectra of the complexes; thus showing that coordination took place at the NH of the diphenylamine. TG and elemental analysis confirmed these results.

Revue / Journal Title

European journal of pharmaceutical sciences   ISSN 0928-0987 

Source / Source

2005, vol. 26, n^o3-4, pp. 341-348 [8 page(s) (article)] (16 ref.)

Langue / Language

Anglais

Editeur / Publisher

Elsevier, Shannon, IRLANDE  (1993) (Revue)

Mots-clés anglais / English Keywords

Enzyme ; Oxidoreductases ; Prostaglandin-endoperoxide synthase ; Enzyme inhibitor ; Arylacetic acid derivatives ; H1 Histamine receptor ; Piperazine derivatives ; Antihistaminic ; Antagonist ; Non steroidal antiinflammatory agent ; Analgesic ; Antipyretic ; Antiasthma agent ; Antiallergic ; Pharmaceutical technology ; Nuclear magnetic resonance ; Molecular adduct ; Diclofenac ; Interaction ; Cetirizine ;

Mots-clés français / French Keywords

Enzyme ; Oxidoreductases ; Prostaglandin-endoperoxide synthase ; Inhibiteur enzyme ; Arylacétique acide dérivé ; Récepteur histaminergique H1 ; Pipérazine dérivé ; Antihistaminique ; Antagoniste ; Antiinflammatoire non stéroïde ; Analgésique ; Antipyrétique ; Antiasthmatique ; Antiallergique ; Technologie pharmaceutique ; Résonance magnétique nucléaire ; Adduit moléculaire ; Diclofénac ; Interaction ; Cétirizine ;

Mots-clés espagnols / Spanish Keywords

Enzima ; Oxidoreductases ; Prostaglandin-endoperoxide synthase ; Inhibidor enzima ; Arilacético ácido derivado ; Receptor histaminérgico H1 ; Piperazina derivado ; Antihistamínico ; Antagonista ; Antiinflamatorio no esteroide ; Analgésico ; Antipirético ; Agente antiasma ; Antialérgico ; Tecnología farmacéutica ; Resonancia magnética nuclear ; Producto adición molecular ; Diclofenaco ; Interacción ; Cetirizina ;

Mots-clés d'auteur / Author Keywords

Diclofenac complexes ; Cetirizine dihydrochloride adducts ; Vibrational spectroscopy ; Nuclear magnetic resonance ;

Localisation / Location

INIST-CNRS, Cote INIST : 26027, 35400013274361.0100