Titre du document / Document title

Efficacy of tibolone and transdermal estrogen therapy on psychological symptoms in women following surgical menopause

Auteur(s) / Author(s)

BAKSU A. ⁽¹⁾ ; AYAS B. ⁽¹⁾ ; CITAK S. ⁽²⁾ ; KALAN A. ⁽¹⁾ ; BAKSU B. ⁽³⁾ ; GOKER N. ⁽¹⁾ ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ 1st Obstetrics and Gynecology Clinic, Şişli Etfal Training and Research Hospital, Istanbul, TURQUIE
⁽²⁾ 2nd Psychiatry Clinic, Bakirkoy State Hospital of Psychiatric and Neurological Disease, Istanbul, TURQUIE
⁽³⁾ 2nd Obstetrics and Gynecology Clinic, Sisli Etfal Training and Research Hospital, Istanbul, TURQUIE

Résumé / Abstract

Objective: This study investigated the efficacy of tibolone and transdermal estradiol therapy on menopausal and psychological symptoms in women following surgical menopause. Method: Seventy-five women who had undergone surgical menopause were randomized to a 6-month double-blind interventional study treatment with oral 2.5 mg/day tibolone, transdermal 3.9 mg/week estradiol or oral placebo. The patients were assessed using Kupperman's Scale, Hamilton Depression Rating Scale (HDRS) and Hamilton Anxiety Rating Scale (HARS) before and at the end of the 6 months of treatment. Result: Sixty-five subjects completed the study: 23 on tibolone, 21 on transdermal estradiol and 21 on placebo. At the end of the 6 months of therapy, highly significant improvements in menopausal symptoms, depression and anxiety scores were observed in both groups (tibolone and transdermal estradiol groups) as compared with baseline values (p<0.001). However, in the placebo group, there were no significant differences on changes from baseline to the end of treatment (p>0.05). Conclusion: These results suggest that tibolone and transdermal estradiol therapy significantly improve menopausal and psychological symptoms in women following surgical menopause.

Revue / Journal Title

International journal of gynaecology and obstetrics   ISSN 0020-7292   CODEN IJGOAL 

Source / Source

2005, vol. 91, n^o1, pp. 58-62 [5 page(s) (article)] (32 ref.)

Langue / Language

Anglais

Editeur / Publisher

Elsevier, Shannon, IRLANDE  (1969) (Revue)

Mots-clés anglais / English Keywords

Sex steroid hormone ; Ovarian hormone ; Corticosteroid ; Obstetrics ; Gynecology ; Menopause ; Estradiol ; Adult ; Female ; Surgery ; Human ; Symptomatology ; Hormone therapy ; Psychology ; Percutaneous route ; Estrogen ; Transdermal system ; Treatment efficiency ; Tibolone ;

Mots-clés français / French Keywords

Hormone stéroïde sexuelle ; Hormone ovarienne ; Corticostéroïde ; Obstétrique ; Gynécologie ; Ménopause ; Estradiol ; Adulte ; Femelle ; Chirurgie ; Homme ; Symptomatologie ; Traitement hormonal ; Psychologie ; Voie percutanée ; Oestrogène ; Système transdermique ; Efficacité traitement ; Tibolone ;

Mots-clés espagnols / Spanish Keywords

Hormona esteroide sexual ; Hormona ovárica ; Corticoesteroide ; Obstétrico ; Ginecología ; Menopausia ; Estradiol ; Adulto ; Hembra ; Cirugía ; Hombre ; Sintomatología ; Hormonoterapia ; Psicología ; Vía percutánea ; Estrógeno ; Sistema transdérmico ; Eficacia tratamiento ; Tibolona ;

Mots-clés d'auteur / Author Keywords

Surgical menopause ; Tibolone ; Transdermal estradiol ; Psychological symptom ;

Localisation / Location

INIST-CNRS, Cote INIST : 15472, 35400013268694.0110