Titre du document / Document title

Pioneer study : PPARγ activation results in overall improvement of clinical and metabolic markers associated with insulin resistance independent of long-term glucose control

Auteur(s) / Author(s)

PFüTZNER A. ; HOHBERG C. ; LüBBEN G. ; PAHLER S. ; PFüTZNER A. H. ; KANN P. ; FORST T. ;

Résumé / Abstract

New scores and biochemical markers have recently been published for diagnosis of insulin resistance and β-cell dysfunction (such as intact proinsulin, adiponectin, IRISII-score). One goal of this 6-month prospective controlled study was to evaluate the impact of pioglitazone (45 mg) vs. glimepiride (1-6 mg, in the intend to optimize therapy) on these markers. Observation parameters were: IRIS-II score, HOMA-score, ATP III score, HbA_1c, fasting glucose, lipids, intact proinsulin, adiponectin, and adverse events. The study was completed by 173 patients (66 female, 107 male, age ′ STD: 63′8 years, disease duration: 7.2′7.2 years, HbA_1c: 7.53′0.85%, pioglitazone arm: 89 patients). The groups were not different for any of the observation parameters at baseline, and a similar reduction in HbA_1c was seen in both groups (p<0.001). In the pioglitazone group, reductions were observed for the IRIS-II and HOMA scores (p < 0.001 vs. glimepiride at endpoint) fasting glucose (p<0.001), insulin (p<0.001), LDL/HDL ratio (p<0.001), hsCRP (p<0.05), intact proinsulin (p<0.001), and an increase was seen in HDL (p<0.001), adiponectin (p<0.001) and BMI (p<0.001). In conclusion, treatment with pioglitazone resulted in an improvement of markers for insulin resistance and p-cell dysfunction, independent from blood glucose control. Adiponectin, intact proinsulin, and the IRIS-II score may be suitable parameters for monitoring of these additional beneficial therapeutic effects.

Revue / Journal Title

Hormone and metabolic research   ISSN 0018-5043   CODEN HMMRA2 

Source / Source

2005, vol. 37, n^o8, pp. 510-515 [6 page(s) (article)]

Langue / Language

Anglais

Editeur / Publisher

Thieme, Stuttgart, ALLEMAGNE  (1969) (Revue)

Mots-clés d'auteur / Author Keywords

Intact proinsulin ; Adiponectin ; IRIS-II score ; HOMA score ;

Localisation / Location

INIST-CNRS, Cote INIST : 14356, 35400013187753.0090