Titre du document / Document title

Relationship of lipoprotein lipase and hepatic triacylglycerol lipase activity to serum adiponectin levels in Japanese hyperlipidemic men

Auteur(s) / Author(s)

KOBAYASHI J. ; KUSUNOKI M. ; MURASE Y. ; KAWASHIRI M. ; HIGASHIKATA T. ; MIWA K. ; KATSUDA S. ; TAKATA M. ; ASANO A. ; NOHARA A. ; INAZU A. ; MABUCHI H. ;

Résumé / Abstract

Objective: The aim of this study was to determine how lipoprotein lipase (LPL) and hepatic triacylglycerol lipase (HTGL) activity relate to serum adiponectin levels. Research design and methods: Fifty-five hyperlipidemic Japanese men were recruited for this study. LPL and HTGL activity in post-heparin plasma (PHP) was measured using Triton X-100 emulsified-[¹⁴C] triolein. The remaining activity in the presence of 1M NaCI was defined as HTGL activity. Serum adiponectin levels were determined by an enzyme-linked immunosorbent assay system. Result: LPL activity had a positive relationship with HDL₂, but had no relation with HDL₃, while HTGL had positive relationship with HDL₃, but had no relationship with HDL₂. LPL activity showed a positive relationship [r= 0.345, p= 0.010] to serum adiponectin levels, while and HTGL activity showed an inverse relationship [r= -0.365 p=0.006]. Multiple regression analysis with LPL and HTGL as dependent variables and age, BMI, serum adiponectin and the homeostasis model assessment of insulin resistance (HOMA-IR) as independent variables showed LPL and HTGL's association to adiponectin did not persist after adjustments for these covariants. However, the association of LPL activity to HOMA-IR was found to persist after adjustments of age, BMI, and serum adiponectin. Conclusions: There was a co-linearity between insulin sensitivity and adiponectin as well as insulin sensitivity and LPL/HTGL activity.

Revue / Journal Title

Hormone and metabolic research   ISSN 0018-5043   CODEN HMMRA2 

Source / Source

2005, vol. 37, n^o8, pp. 505-509 [5 page(s) (article)]

Langue / Language

Anglais

Editeur / Publisher

Thieme, Stuttgart, ALLEMAGNE  (1969) (Revue)

Mots-clés d'auteur / Author Keywords

Adiponectin ; Hepatic triacylglycerol lipase ; Lipoprotein lipase ;

Localisation / Location

INIST-CNRS, Cote INIST : 14356, 35400013187753.0080