Titre du document / Document title

Evaluation of dika nut mucilage (Irvingia gabonensis) as binding agent in metronidazole tablet formulations

Auteur(s) / Author(s)

ODEKU Oluwatoyin A. ⁽¹⁾ ; PATANI Bernard O. ⁽¹⁾ ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, University of Ibadan, Ibadan, NIGERIA

Résumé / Abstract

Dika nut mucilage obtained from the nuts of Irvingia gabonensis (O'Rorke) Bail (family Irvingiaceae) has been evaluated as a binding agent in metronidazole tablet formulations in comparison with gelatin BP. The compressional properties of metronidazole formulations were analyzed using density measurements and the Heckel equations as assessment parameters, whereas the mechanical properties of the tablets were assessed using the tensile strength (T), brittle fracture index (BFI), and the friability of the tablets. The drug release properties of the tablets were assessed using disintegration and dissolution times of the tablets. The results obtained indicate that formulations containing dika nut mucilage as binding agent show faster onset of plastic deformation under compression pressure than those containing gelatin. The tensile strength of the tablets increased with increase in concentration of the binding agents, whereas the BFI and friability values decreased. Furthermore, tablets containing dika nut mucilage generally showed lower tensile strength but higher brittleness and friability than those containing gelatin. The results also showed that tablets containing dika nut mucilage generally showed higher disintegration and dissolution times than those containing gelatin BP. The results suggest that dika nut mucilage could be useful in achieving various tablet strength and drug release properties.

Revue / Journal Title

Pharmaceutical development and technology   ISSN 1083-7450 

Source / Source

2005, vol. 10, n^o3, pp. 439-446 [8 page(s) (article)] (22 ref.)

Langue / Language

Anglais

Editeur / Publisher

Informa Healthcare, New York, NY, ETATS-UNIS  (1996) (Revue)

Mots-clés anglais / English Keywords

Dosage form ; Imidazole derivatives ; Nitro compound ; Antiprotozoal agent ; Antifungal agent ; Parasiticide ; Pharmaceutical technology ; Gelatin ; Formulation ; Tablet ; Metronidazole ; Binding ; Evaluation ;

Mots-clés français / French Keywords

Forme pharmaceutique ; Imidazole dérivé ; Composé nitro ; Antiprotozoaire ; Antifongique ; Antiparasitaire ; Technologie pharmaceutique ; Gélatine ; Formulation ; Comprimé ; Métronidazole ; Liaison ; Evaluation ;

Mots-clés espagnols / Spanish Keywords

Forma farmacéutica ; Imidazol derivado ; Compuesto nitro ; Antiprotozoario ; Antifúngico ; Antiparasitario ; Tecnología farmacéutica ; Gelatina ; Formulación ; Tableta ; Metronidazol ; Enlace ; Evaluación ;

Mots-clés d'auteur / Author Keywords

dika nut mucilage ; gelatin ; binding agent ; metronidazole ; tablet ;

Localisation / Location

INIST-CNRS, Cote INIST : 26544, 35400013173845.0110