Titre du document / Document title

Influence of misoprostol (PGE1) on amniotic fluid and maternal serum adrenomedullin levels

Auteur(s) / Author(s)

HASCALIK Seyma ⁽¹⁾ ; CELIK Onder ⁽¹⁾ ; DOGRU M. Ilker ⁽²⁾ ; DOGRU Arzu Kocagun ⁽²⁾ ; INAN Esma ⁽¹⁾ ; YUREKLI Muhittin ⁽²⁾ ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ Department of Obstetrics and Gynecology, Inonu University, Malatya, TURQUIE
⁽²⁾ Department of Molecular Biology, Inonu University, Malatya, TURQUIE

Résumé / Abstract

Objective. The purpose of this study was to determine the levels of adrenomedullin (AdM) in amniotic fluid (AF) and maternal serum of misoprostol (PGE1)-induced pregnant women. Materials and methods. A total of 40 women were included in the study: 20 were in active labor and were delivered vaginally and a further 20 were not in labor and misoprostol induction was performed. Women who were undergoing labor induction received 50 pg of misoprostol, which was placed in the posterior fornix of the vagina every 4 hrs until the onset of labor. In each patient, maternal plasma and AF samples were collected. Samples of AF were collected by transvaginal route at the time of rupture of the membranes. The labor was at the same stage in both the groups during the sample collection. In all pregnant subjects, maternal blood samples were drawn from the cubital vein at the time of AF sampling. Amniotic fluid and serum AdM concentration was measured by using reverse-phase high-performance liquid chromatography. Results. Misoprostol-induced pregnant women showed significantly higher AdM concentrations than control pregnant women in AF (79.48 ± 6.14 pmol/ml versus 21.28 ± 0.90 pmol/ml, P = 0.000) and maternal serum (88.20 ± 4.34 pmol/ml versus 29.78 ± 4.51 pmol/ml, P = 0.000). There was no significant difference between maternal serum and AF-AdM concentrations in misoprostol and control subjects. Conclusion. Increased serum and AF-AdM concentrations may be necessary to initiate cervical ripening in misoprostol-induced pregnant women.

Revue / Journal Title

Acta obstetricia et gynecologica Scandinavica   ISSN 0001-6349   CODEN AOGSAE 

Source / Source

2005, vol. 84, n^o9, pp. 833-836 [4 page(s) (article)] (30 ref.)

Langue / Language

Anglais

Editeur / Publisher

Taylor & Francis, Colchester, ROYAUME-UNI  (1925) (Revue)

Mots-clés anglais / English Keywords

Prostaglandin derivatives ; Obstetrics ; Gynecology ; Ripening ; Uterine cervix ; Adrenomedullin ; Serum ; Mother ; Amniotic fluid ; Misoprostol ;

Mots-clés français / French Keywords

Prostaglandine dérivé ; Obstétrique ; Gynécologie ; Maturation ; Col utérus ; Adrénomédulline ; Sérum ; Mère ; Liquide amniotique ; Misoprostol ;

Mots-clés espagnols / Spanish Keywords

Prostaglandina derivado ; Obstétrico ; Ginecología ; Maduración ; Cuello útero ; Adrenomedulina ; Suero ; Madre ; Líquido amniótico ; Misoprostol ;

Mots-clés d'auteur / Author Keywords

adrenomedullin ; misoprostol ; amniotic fluid ; serum ; cervical ripening ;

Localisation / Location

INIST-CNRS, Cote INIST : 964 A, 35400013242780.0020