Titre du document / Document title

Turning signals on and off : GLUT4 traffic in the insulin-signaling highway

Auteur(s) / Author(s)

THONG Farah S. L. ; DUGANI Chandrasagar B. ; KLIP Amira ;

Résumé / Abstract

Insulin stimulation of glucose uptake into skeletal muscle and adipose tissues is achieved by accelerating glucose transporter GLUT4 exocytosis from intracellular compartments to the plasma membrane and minimally reducingits endocytosis. The round trip of GLUT4 is intricately regulated by diverse signaling molecules impinging on specific compartments. Here we highlight the key molecular signals that are turned on and off by insulin to accomplish this task.

Revue / Journal Title

Physiology   ISSN 1548-9213 

Source / Source

2005, vol. 20, n^oaou, pp. 271-284 [14 page(s) (article)]

Langue / Language

Anglais

Editeur / Publisher

International Union of Physiological Society, Bethesda, MD, ETATS-UNIS  (2004) (Revue)

Localisation / Location

INIST-CNRS, Cote INIST : 21347, 35400013835682.0070