Titre du document / Document title

Proficiency testing (external quality assessment) of drug detection in oral fluid

Auteur(s) / Author(s)

CLARKE Joe ⁽¹⁾ ; WILSON John F. ⁽²⁾ ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ Altrix Healthcare plc, Birchwood Science Park, Warrington WA3 7BP, ROYAUME-UNI
⁽²⁾ Department of Pharmacology, Therapeutics and Toxicology, Wales College of Medicine, Cardiff University. Heath Park, Cardiff CF14 4XN, ROYAUME-UNI

Résumé / Abstract

Eighteen external quality assessment (proficiency testing) samples were prepared from client specimens collected with the Intercept® oral fluid collection device and by spiking drug-free oral fluid. Samples were circulated in pairs at quarterly intervals to 13 UK and USA based laboratories for analysis by a panel ofOraSure micro-plate Intercept® enzyme immunoassay kits and hyphenated mass spectrophotometric techniques. During the survey, there was a single case of non-specificity in a false report for methadone. The major errors were of lack of sensitivity relative to the concentration thresholds specified for the immunoassays. The sensitivity for overall 'present'/'not found' reports calculated as true positives/(true positives + false negatives) were for the amfetamine specific assay 50%, methyl-amfetamines 93%, barbiturates 64%, cannabinoids 73%, cocaine and metabolites 100%, benzodiazepines 69%, methadone 95%, opiates 79% (opiates excluding oxycodone 93%), phencyclidine 93% and human gamma-globulin 97%. A small number of the sensitivity errors were attributable to errors in chromatographic confirmation techniques.

Revue / Journal Title

Forensic science international   ISSN 0379-0738   CODEN FSINDR 

Source / Source

2005, vol. 150, n^o 2-3 (130 p.)  [Document : 4 p.] (8 ref.), pp. 161-164 [4 page(s) (article)]

Langue / Language

Anglais

Editeur / Publisher

Elsevier, Kidlington, ROYAUME-UNI  (1978) (Revue)

Mots-clés anglais / English Keywords

Ester ; Amphetamine derivatives ; Local anesthetic ; CNS stimulant ; Psychotropic ; Forensic science ; Forensic aspect ; Legal medicine ; Globulin ; Human ; Opiates ; Cannabinoid ; Saliva ; Detection ; Quality control ; Cocaine ; External ; Drug of abuse ; Amfetamine ; Toxicological exploration ; Medical screening ; Drug test ;

Mots-clés français / French Keywords

Ester ; Amphétamine dérivé ; Anesthésique local ; Stimulant SNC ; Psychotrope ; Police scientifique ; Aspect médicolégal ; Médecine légale ; Globuline ; Homme ; Opiacés ; Cannabinoïde ; Salive ; Détection ; Contrôle qualité ; Cocaïne ; Externe ; Substance toxicomanogène ; Amfétamine ; Exploration toxicologique ; Dépistage ; Drogue test ;

Mots-clés espagnols / Spanish Keywords

Ester ; Amfetamina derivado ; Anestésico local ; Estimulante SNC ; Psicotropo ; Ciencia forense ; Aspecto forense ; Medicina legal ; Globulina ; Hombre ; Opiados ; Canabinoide ; Saliva ; Detección ; Control calidad ; Cocaína ; Externo ; Sustancia toxicomanógena ; Anfetamina ; Análisis toxicológico ; Descubrimiento ; Prueba de la droga ;

Mots-clés d'auteur / Author Keywords

Proficiency ; Oral fluid ; Amfetamines ; Cannabinoids ; Cocaine ; Opiates ; Human gamma-globulin ;

Localisation / Location

INIST-CNRS, Cote INIST : 15440, 35400012477643.0050