Titre du document / Document title

Increased prevalence of factor V leiden in patients with retinal vein occlusion and under 60 years of age

Auteur(s) / Author(s)

ARSENE Sophie ⁽¹⁾ ; DELAHOUSSE Bénédicte ⁽²⁾ ; REGINA Sandra ^{(2 3)} ; LE LEZ Marie-Laure ⁽¹⁾ ; PISELLA Pierre-Jean ⁽¹⁾ ; GRUEL Yves ^{(2 3)} ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ Department of Ophthalmology, Centre Hospitalier Universitaire Bretonneau, Tours, FRANCE
⁽²⁾ Department of Hematology-Hemostasis, Centre Hospitalier Universitaire Trousseau, Tours, FRANCE
⁽³⁾ Inserm, U618, Tours, FRANCE

Résumé / Abstract

Retinal vein occlusion (RVO) is a multifactorial disease involving vessel damage, stasis, viscosity and thrombosis. Conflicting findings on hereditary thrombophilic risk factors have been reported and their impact on RVO features remains to be defined. The aim of the present study was to evaluate the prevalence of hereditary thrombophilic risk factors (HTRF) and characteristics of RVO in patients with or without HTRF. The design of the study was a prospective, observational case series.Two hundred and thirty-four patients with RVO were included consecutively. A French healthy population of the same region was studied as control group.The HTRF studied were protein C (PC), protein S (PS) and antithrombin (AT) deficiencies, factor V Leiden (FVL) and factor II 2021 OA polymorphisms. Chi-Square was used for comparison with the healthy subjects and between RVO patient with and without HTRF according to localisation (branch vs. central), type of RVO (ischemic or non-ischemic), recurrence, age at first event and classical vascular risk factors.Twenty-two patients had HTRF (12 FV Leiden heterozygotes, 9 Fll 2021 OA heterozygotes and I PS deficiency). No AT or PC deficiency was detected. Frequencies of PS deficiency, FVL and Fll 2021 OA allele were similar to the reference population as well as to published data in the general caucasian population. Eighty-six patients experienced their first episode before the age of 60 years. Systemic hypertension, glaucoma and angina were significantly less frequent in patients with RVO before 60 years. Fourteen of the 22 patients with one HTRF (64%) experienced their first episode of RVO before the age of 60 years compared to 72 of 212 without HTRF (34%) (p = 0.006). Heterozygote status for FV Leiden was significantly more frequent in patients who had experienced their first episode of RVO before 60 years (p = 0.027). In conclusion,this study suggests a role of FV Leiden in the occurrence of RVO in patients younger than 60 years who exhibit fewer acquired vascular risk factors than in older patients.

Revue / Journal Title

Thrombosis and haemostasis   ISSN 0340-6245   CODEN THHADQ 

Source / Source

2005, vol. 94, n^o1, pp. 101-106 [6 page(s) (article)] (32 ref.)

Langue / Language

Anglais

Editeur / Publisher

Schattauer, Stuttgart, ALLEMAGNE  (1976) (Revue)

Mots-clés anglais / English Keywords

Venous disease ; Vascular disease ; Retinopathy ; Eye disease ; Cardiovascular disease ; Risk factor ; Hereditary ; Central retinal vein occlusion ; Age ; Human ; Thrombophilia ; Epidemiology ; Prevalence ; Factor V Leiden ;

Mots-clés français / French Keywords

Veine pathologie ; Vaisseau sanguin pathologie ; Rétinopathie ; Oeil pathologie ; Appareil circulatoire pathologie ; Facteur risque ; Héréditaire ; Thrombose veine centrale rétine ; Age ; Homme ; Thrombophilie ; Epidémiologie ; Prévalence ; Facteur V Leiden ;

Mots-clés espagnols / Spanish Keywords

Vena patología ; Vaso sanguíneo patología ; Retinopatía ; Ojo patología ; Aparato circulatorio patología ; Factor riesgo ; Hereditario ; Trombosis de la vena central de la retina ; Edad ; Hombre ; Trombofilia ; Epidemiología ; Prevalencia ; Factor V Leiden ;

Mots-clés d'auteur / Author Keywords

Retinal vein occlusion ; Factor V Leiden ; hereditary thrombosis risk factors ;

Localisation / Location

INIST-CNRS, Cote INIST : 10255, 35400013219606.0160