Titre du document / Document title

Omeprazole delays gastric emptying in healthy volunteers : an effect prevented by tegaserod

Auteur(s) / Author(s)

TOUGAS G. ^{(1 2)} ; EARNEST D. L. ⁽³⁾ ; CHEN Y. ⁽¹⁾ ; VANDERKOY C. ⁽¹⁾ ; ROJAVIN M. ⁽³⁾ ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ McMaster University, Hamilton, ON, CANADA
⁽²⁾ Novartis Pharma AG, Basel, SUISSE
⁽³⁾ Novartis Pharmaceuticals, East Hanover, NJ, ETATS-UNIS

Résumé / Abstract

Background: Proton-pump inhibitors effectively suppress stomach acidity. They are widely used for treating gastro-oesophageal reflux disease and related conditions. While generally safe, omeprazole and other proton-pump inhibitors can delay gastric emptying. Aim: To test the hypothesis that tegaserod can normalize or prevent omeprazole-induced delay in gastric emptying. Methods: This was a randomized, double-blind, placebo-controlled, parallel group study in 40 healthy male volunteers. After informed consent and screening, qualified volunteers were treated with unblinded omeprazole 20 mg b.d. and either blinded tegaserod 6 mg t.d.s. (active treatment group) or placebo-matching tegaserod t.d.s. (control group) for 14 days. Gastric emptying was assessed before and after treatment, using a scintigraphy method. Results: Omeprazole monotherapy significantly delayed gastric emptying expressed by duration of lag-phase (P < 0.007), time to gastric half-emptying (P < 0.003), and gastric retention of the meal at 60 (P < 0.002) and 120 min (P < 0.04) after its ingestion. Tegaserod taken together with omeprazole effectively prevented development of the above effects. Combined treatment was safe and well tolerated. Conclusion: Concomitant administration of tegaserod 6 mg t.d.s. prevented development of the delayed gastric emptying induced by omeprazole monotherapy.

Revue / Journal Title

Alimentary pharmacology & therapeutics   ISSN 0269-2813 

Source / Source

2005, vol. 22, n^o1, pp. 59-65 [7 page(s) (article)] (24 ref.)

Langue / Language

Anglais

Editeur / Publisher

Blackwell, Oxford, ROYAUME-UNI  (1987) (Revue)

Mots-clés anglais / English Keywords

5-HT4 Serotonine receptor ; Partial agonist ; Stomach ; Digestive system ; Proton pump inhibitor ; Enzyme inhibitor ; Enzyme ; Hydrolases ; H⁺/K⁺-exchanging ATPase ; Benzimidazole derivatives ; Antiulcer agent ; Antisecretory agent ; Tegaserod ; Prevention ; Human ; Healthy subject ; Gastric emptying ; Omeprazole ;

Mots-clés français / French Keywords

Récepteur sérotoninergique 5-HT4 ; Agoniste partiel ; Estomac ; Appareil digestif ; Inhibiteur pompe proton ; Inhibiteur enzyme ; Enzyme ; Hydrolases ; H⁺/K⁺-exchanging ATPase ; Benzimidazole dérivé ; Antiulcéreux ; Antisécrétoire ; Tégasérod ; Prévention ; Homme ; Individu sain ; Evacuation gastrique ; Oméprazole ;

Mots-clés espagnols / Spanish Keywords

Receptor serotoninérgico 5-HT4 ; Agonista parcial ; Estómago ; Aparato digestivo ; Inhibidor bomba protón ; Inhibidor enzima ; Enzima ; Hydrolases ; H⁺/K⁺-exchanging ATPase ; Benzimidazol derivado ; Antiulceroso ; Antisecretorio ; Tegaserod ; Prevención ; Hombre ; Individuo sano ; Vaciamiento gástrico ; Omeprazol ;

Localisation / Location

INIST-CNRS, Cote INIST : 21831, 35400013816963.0080