Titre du document / Document title

A search for anti-viral properties in Panamanian medicinal plants. The effects on HIV and its essential enzymes

Auteur(s) / Author(s)

MATSUSE I. T. ⁽¹⁾ ; LIMB Y. A. ⁽²⁾ ; HATTORI M. ⁽²⁾ ; CORREA M. ⁽³⁾ ; GUPTA M. P. ⁽⁴⁾ ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ Faculty of Medicine, Toyama Medical and Pharmaceutical University, Toyama, JAPON
⁽²⁾ Research Institute for Traditional Sino-Japanese Medicines, Toyama Medical and Pharmaceutical University, Toyama, JAPON
⁽³⁾ Herbarium of the University of Panama, Panama City, PANAMA
⁽⁴⁾ College of Pharmacy, University of Panama, Panama City, PANAMA

Résumé / Abstract

Aqueous and methanolic extracts of 39 Panamanian medicinal plants were tested for anti-human immunodeficiency virus (HIV) effects. The extracts were tested for the inhibition of HIV-induced cytopathic effects in cultured cells, HIV-reverse transcriptase (RT) and HIV-protease (PR) enzymes. The water extract of the branches of Jatropha curcas (Euphorbiaceae) inhibited strongly the HIV-induced cytopathic effects with low cytotoxicity. On the other hand, the water extracts of the whole plant of Chamaesyce hyssopifolia (Euphorbiaceae), the leaves of Cordia spinescens (Boraginaceae) and the aerial parts of Hyptis lantanifolia (Labiatae), and the methanol extract of the aerial parts of Tetrapteris macrocarpa (Malpighiaceae) were potent inhibitors of HIV-RT (IC₅₀: 6-8 μg/ml). Seven out of 39 plants were found to be moderate inhibitors of HIV-PR (IC₅₀: 43-100 μg/ml). Furthermore, we report on the respective inhibitory substances of J. curcas, C. hyssopifolia and C. spinescens, and their possible mechanism of action.

Revue / Journal Title

Journal of ethnopharmacology   ISSN 0378-8741   CODEN JOETD7 

Source / Source

1999, vol. 64, n^o1, pp. 15-22 (16 ref.)

Langue / Language

Anglais

Editeur / Publisher

Elsevier, Shannon, IRLANDE  (1978) (Revue)

Mots-clés anglais / English Keywords

Plant origin ; Medicinal plant ; Panama ; Floral survey ; Antiviral ; HIV-1 virus ; Biological activity ; In vitro ; RNA-directed DNA polymerase ; Peptidases ; Extract ; Plant leaf ; Above ground plant part ; Cytotoxicity ; Pharmacognosy ; Central America ; America ; Boraginaceae ; Dicotyledones ; Angiospermae ; Spermatophyta ; Human immunodeficiency virus ; Lentivirus ; Retroviridae ; Virus ; Labiatae ; Nucleotidyltransferases ; Transferases ; Enzyme ; Hydrolases ; Jatropha ; Euphorbiaceae ; Malpighiaceae ;

Mots-clés français / French Keywords

Origine végétale ; Plante médicinale ; Panama ; Inventaire floristique ; Antiviral ; Virus HIV1 ; Activité biologique ; In vitro ; RNA-directed DNA polymerase ; Peptidases ; Extrait ; Feuille végétal ; Partie aérienne végétal ; Cytotoxicité ; Pharmacognosie ; Jatropha curcas ; Chamaesyce hyssopifolia ; Cordia spinescens ; Hyptis lantanifolia ; Tetrapteris macrocarpa ; Amérique Centrale ; Amérique ; Boraginaceae ; Dicotyledones ; Angiospermae ; Spermatophyta ; Virus immunodéficience humaine ; Lentivirus ; Retroviridae ; Virus ; Labiatae ; Nucleotidyltransferases ; Transferases ; Enzyme ; Hydrolases ; Jatropha ; Euphorbiaceae ; Malpighiaceae ;

Mots-clés espagnols / Spanish Keywords

Origen vegetal ; Planta medicinal ; Panamá ; Inventario flora ; Antiviral ; HIV-1 virus ; Actividad biológica ; In vitro ; RNA-directed DNA polymerase ; Peptidases ; Extracto ; Hoja vegetal ; Parte aérea vegetal ; Citotoxicidad ; Farmacognosia ; America central ; America ; Boraginaceae ; Dicotyledones ; Angiospermae ; Spermatophyta ; Human immunodeficiency virus ; Lentivirus ; Retroviridae ; Virus ; Labiatae ; Nucleotidyltransferases ; Transferases ; Enzima ; Hydrolases ; Jatropha ; Euphorbiaceae ; Malpighiaceae ;

Localisation / Location

INIST-CNRS, Cote INIST : 18028, 35400007404552.0030