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Titre du document / Document title

Elevated plasma citrulline and arginine due to consumption of Citrullus vulgaris (watermelon)

Auteur(s) / Author(s)

MANDEL H. (1) ; LEVY N. (2) ; IZKOVITCH S. (3) ; KORMAN S. H. (4) ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

(1) Metabolic Unit, Meyer Children's Hospital, ISRAEL
(2) Department of Clinical Nutrition, Meyer Children's Hospital, ISRAEL
(3) Department of Clinical Biochemistry, Rambam Medical Center, Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, ISRAEL
(4) Department of Clinical Biochemistry, Hadassah - Hebrew University Medical Center, Jerusalem, ISRAEL

Résumé / Abstract

A 19-month-old girl with developmental delay was found to have moderately elevated plasma citrulline and mildly elevated plasma arginine concentrations. Dietary history revealed that she consumed large quantities of watermelon (Citrullus vulgaris), a fruit containing high free citrulline and arginine concentrations. In order to determine whether the patient's high watermelon intake could account for her elevated plasma citrulline and arginine concentrations, we studied the response of plasma citrulline and arginine to ingestion of watermelon in six healthy adult volunteers. All developed markedly elevated plasma citrulline (mean maximum 593 μmol/L, range 386-1069) and moderately elevated plasma arginine (mean maximum 199 μmol/L, range 128-251). Physicians and laboratory personnel performing metabolic investigations should be aware of watermelon-induced citrullinaemia. Its hallmarks are elevated plasma citrulline, and to a lesser extent arginine, in the absence of orotic or arginosuccinic aciduria or hyperammonaemia. This phenomenon has implications for the management of patients with urea cycle and related disorders.

Revue / Journal Title

Journal of inherited metabolic disease    ISSN  0141-8955   CODEN JIMDDP 

Source / Source

2005, vol. 28, no4, pp. 467-472 [6 page(s) (article)] (12 ref.)

Langue / Language

Anglais

Editeur / Publisher

Springer, Heidelberg, ALLEMAGNE  (1978) (Revue)

Mots-clés anglais / English Keywords

Aminoacid

;

Nutrition

;

Metabolic diseases

;

Genetics

;

Consumption

;

Citrulline

;

Blood plasma

;

Arginine

;

Mots-clés français / French Keywords

Aminoacide

;

Nutrition

;

Métabolisme pathologie

;

Génétique

;

Consommation

;

Citrulline

;

Plasma sanguin

;

Arginine

;

Mots-clés espagnols / Spanish Keywords

Aminoácido

;

Nutrición

;

Metabolismo patología

;

Genética

;

Consumo

;

Citrulina

;

Plasma sanguíneo

;

Arginina

;

Localisation / Location

INIST-CNRS, Cote INIST : 18251, 35400012496957.0030

Nº notice refdoc (ud4) : 16852678



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