Titre du document / Document title

Patient stratification in the management of acute bacterial exacerbation of chronic bronchitis : the role of levofloxacin 750 mg

Auteur(s) / Author(s)

MARTINEZ F. J. ⁽¹⁾ ; GROSSMAN R. F. ⁽²⁾ ; ZADEIKIS N. ⁽³⁾ ; FISHER A. C. ⁽³⁾ ; WALKER K. ⁽⁴⁾ ; AMBRUZS M. E. ⁽³⁾ ; TENNENBERG A. M. ⁽⁵⁾ ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ Pulmonary Dept, University of Michigan, Ann Arbor, MI, ETATS-UNIS
⁽²⁾ Mount Sinai Hospital, Toronto, CANADA
⁽³⁾ Ortho-McNeil Pharmaceutical. Inc, Raritan, ETATS-UNIS
⁽⁴⁾ Riverview Medical Center, Red Bank, NJ, ETATS-UNIS
⁽⁵⁾ Tibotec Inc, Yardley, PA, ETATS-UNIS

Résumé / Abstract

This is the first prospective clinical trial in which patients with acute bacterial exacerbation of chronic bronchitis have been stratified by degree of underlying illness. Uncomplicated patients were randomised to levofloxacin 750 mg once daily (q.d.) for 3 days or azithromycin q.d. for 5 days. Complicated patients were randomised to levofloxacin 750 mg q.d. for 5 days or amoxicillin 875 mg/clavulanate 125 mg twice daily for 10 days. Regardless of therapy, complicated patients demonstrated lower clinical and microbiological success than uncomplicated patients. Clinical success for clinically evaluable patients was similar for levofloxacin and azithromycin (93.0 versus 90.1%, respectively), and levofloxacin and amoxicillin/clavulanate (79.2 versus 81.7%, respectively). For microbiologically evaluable patients, clinical response to levofloxacin for 3 days was superior to azithromycin for 5 days (96.3 versus 87.4%, respectively), and levofloxacin for 5 days was similar to amoxicillin/ clavulanate for 10 days (81.4 versus 80.9%, respectively). Microbiological eradication was superior for levofloxacin for 3 days compared with azithromycin for 5 days (93.8 versus 82.8%, respectively), and similar for levofloxacin and amoxicillin/clavulanate for 10 days (81.4 versus 79.8%, respectively). In conclusion, levofloxacin 750 mg for 3 days was comparable to azithromycin for 5 days for uncomplicated patients with acute bacterial exacerbation of chronic bronchitis, while 5 days of 750 mg levofloxacin was comparable to 10 days of amoxicillin/clavulanate for complicated acute bacterial exacerbation of chronic bronchitis.

Revue / Journal Title

The European respiratory journal   ISSN 0903-1936 

Source / Source

2005, vol. 25, n^o6, pp. 1001-1010 [10 page(s) (article)] (35 ref.)

Langue / Language

Anglais

Editeur / Publisher

Maney, Leeds, ROYAUME-UNI  (1988) (Revue)

Mots-clés anglais / English Keywords

Bronchus disease ; Respiratory disease ; Infection ; Antibiotic ; Antibacterial agent ; Risk ; Risk factor ; Chronic ; Acute ; Stratification ; Human ; Azithromycin ; Amoxicillin ; Levofloxacin ; Bronchitis ; Bacteriosis ;

Mots-clés français / French Keywords

Bronche pathologie ; Appareil respiratoire pathologie ; Infection ; Antibiotique ; Antibactérien ; Risque ; Facteur risque ; Chronique ; Aigu ; Stratification ; Homme ; Azithromycine ; Amoxicilline ; Lévofloxacine ; Bronchite ; Bactériose ;

Mots-clés espagnols / Spanish Keywords

Bronquio patología ; Aparato respiratorio patología ; Infección ; Antibiótico ; Antibacteriano ; Riesgo ; Factor riesgo ; Crónico ; Agudo ; Estratificación ; Hombre ; Azitromicina ; Amoxicilina ; Levofloxacino ; Bronquitis ; Bacteriosis ;

Mots-clés d'auteur / Author Keywords

Acute bacterial exacerbation of chronic bronchitis ; amoxicillin/clavulanate ; azithromycin ; chronic bronchitis ; levofloxacin ; risk assessment ;

Localisation / Location

INIST-CNRS, Cote INIST : 4275, 35400012473287.0110