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Titre du document / Document title

Zinc therapy increases duodenal concentrations of metallothionein and iron in Wilson's disease patients

Auteur(s) / Author(s)

STURNIOLO G. C. ; MESTRINER C. ; IRATO P. ; ALBERGONI V. ; LONGO G. ; D'INCA R. ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

Division of Gastroenterology, Department of Biology, University of Padua, Padua, INDE
Department of Internal Medicine, University of Messina, Messina, ITALIE

Résumé / Abstract

Objective: Wilson's disease is effectively treated by zinc administration which, in vitro, increases metallothionein concentrations. To ascertain whether the latter also occurs in humans we measured metallothionein and trace element concentrations in the duodenal mucosa of 15 Wilson's disease patients: 12 treated with zinc sulphate, two treated with penicillamine, and one not yet on treatment. The control group consisted of 17 patients with dyspepsia, who underwent the same study protocol. Methods: Metallothionein and trace element concentrations were measured in duodenal mucosa biopsies according to the silver-saturation hemolysate method and atomic absorption spectrophotometry. Results: Metallothionein concentrations increased by 1500% after zinc and 150% after penicillamine in Wilson's disease patients, with respect to controls who had negative endoscopy and Wilson's disease patients who were not treated. A significant correlation was found between metallothionein and duodenal zinc concentrations. Mucosal iron concentration increased in Wilson's disease patients whether they were treated with zinc or penicillamine. Duodenum with duodenitis also had significantly increased iron levels compared with normal duodenum. Conclusions: Zinc administration increases intestinal metallothionein in Wilson's disease patients. The blockade of copper absorption and its elimination in the stools on desquamation of the intestinal cells probably explains one of the mechanisms underlying the effect of zinc treatment. Despite normal endoscopy, Wilson's disease patients present increased mucosal iron concentrations similar to those in controls with duodenitis. Metallothionein may therefore prevent oxidative damage caused by metal toxicity.

Revue / Journal Title

The American journal of gastroenterology    ISSN  0002-9270 

Source / Source

1999, vol. 94, no2, pp. 334-338 (29 ref.)

Langue / Language

Anglais

Editeur / Publisher

Nature Publishing Group, Basingstoke, ROYAUME-UNI  (1954) (Revue)

Mots-clés anglais / English Keywords

Wilson disease

;

Chemotherapy

;

Trace element (nutrient)

;

Zinc

;

Secondary effect

;

Drug

;

Increase

;

Concentration factor

;

Duodenum

;

Metallothionein

;

Iron

;

Exploration

;

Human

;

Enzymopathy

;

Metabolic diseases

;

Nervous system diseases

;

Digestive diseases

;

Genetic disease

;

Pharmacovigilance

;

Mots-clés français / French Keywords

Wilson maladie

;

Chimiothérapie

;

Oligoélément

;

Zinc

;

Effet secondaire

;

Médicament

;

Augmentation

;

Taux concentration

;

Duodénum

;

Métallothionéine

;

Fer

;

Exploration

;

Homme

;

Enzymopathie

;

Métabolisme pathologie

;

Système nerveux pathologie

;

Appareil digestif pathologie

;

Maladie héréditaire

;

Pharmacovigilance

;

Mots-clés espagnols / Spanish Keywords

Wilson enfermedad

;

Quimioterapia

;

Oligoelemento

;

Zinc

;

Efecto secundario

;

Medicamento

;

Aumentación

;

Indice concentración

;

Duodeno

;

Metalotioneina

;

Hierro

;

Exploración

;

Hombre

;

Enzimopatía

;

Metabolismo patología

;

Sistema nervioso patología

;

Aparato digestivo patología

;

Enfermedad hereditaria

;

Farmacovigilancia

;

Localisation / Location

INIST-CNRS, Cote INIST : 11062, 35400007421689.0080

Nº notice refdoc (ud4) : 1681752



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