Titre du document / Document title

Molecular pathogenesis of euthyroid and toxic multinodular goiter

Auteur(s) / Author(s)

KROHN Knut ^{(1 2)} ; FÜHRER Dagmar ⁽¹⁾ ; BAYER Yvonne ⁽¹⁾ ; ESZLINGER Markus ⁽¹⁾ ; BRAUER Volker ⁽¹⁾ ; NEUMANN Susanne ⁽¹⁾ ; PASCHKE Ralf ⁽¹⁾ ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ III. Medical Department, University of Leipzig, 04103 Leipzig, ALLEMAGNE
⁽²⁾ Interdisciplinary Center for Clinical Research Leipzig, University of Leipzig, 04103 Leipzig, ALLEMAGNE

Résumé / Abstract

The purpose of this review is to summarize current knowledge of the etiology of euthyroid and toxic multinodular goiter (MNG) with respect to the epidemiology, clinical characteristics, and molecular pathology. In reconstructing the line of events from early thyroid hyperplasia to MNG we will argue the predominant neoplastic character of nodular structures, the nature of known somatic mutations, and the importance of mutagenesis. Furthermore, we outline direct and indirect consequences of these somatic mutations for thyroid pathophysiology and summarize information concerning a possible genetic background of euthyroid goiter. Finally, we discuss uncertainties and open questions in differential diagnosis and therapy of euthyroid and toxic MNG.

Revue / Journal Title

Endocrine reviews   ISSN 0163-769X   CODEN ERVIDP 

Source / Source

2005, vol. 26, n^o4, pp. 504-524 [21 page(s) (article)] (307 ref.)

Langue / Language

Anglais

Editeur / Publisher

Endocrine Society, Bethesda, MD, ETATS-UNIS  (1980) (Revue)

Mots-clés anglais / English Keywords

Thyroid diseases ; Endocrinopathy ; Goiter ; Review ; Pathogenesis ;

Mots-clés français / French Keywords

Thyroïde pathologie ; Endocrinopathie ; Goitre ; Article synthèse ; Pathogénie ;

Mots-clés espagnols / Spanish Keywords

Tiroides patología ; Endocrinopatía ; Bocio ; Artículo síntesis ; Patogenia ;

Localisation / Location

INIST-CNRS, Cote INIST : 18360, 35400012491560.0020