Titre du document / Document title

Doxazosin GITS versus standard doxazosin in mild to moderate hypertension

Auteur(s) / Author(s)

CALVO Carlos ⁽¹⁾ ; GIL-EXTREMERA Bias ⁽²⁾ ; GOMEZ-FERNANDEZ Pablo ⁽³⁾ ; MASRAMON Xavier ⁽⁴⁾ ; PUEYO Carol ⁽⁵⁾ ; ARMADA Beatriz ⁽⁵⁾ ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ Unidad de Hipertensión y Riesgo Vascular, Hospital Clínico Univeritario, Travesia de la Choupana s/n, 15706 Santiago de Compostela, ESPAGNE
⁽²⁾ Medicina Interna, Hospital Universitario San Cecilio de Granada, Avenida Del Dr. Oloriz, 16, 18012 Granada, ESPAGNE
⁽³⁾ Nefrología, Hospital General de Jerez de la Frontera, Ctra. de Circunvalación s/n, 1140 Jerez de la Frontera, ESPAGNE
⁽⁴⁾ Euroclin Institute, C/Diputació 284, 08009 Barcelona, ESPAGNE
⁽⁵⁾ Pfizer S. A., Avenida de Europa 20B, Parque Empresarial de La Moraleja, 28108 Alcobendas, Madrid, ESPAGNE

Résumé / Abstract

Background: The selective α₁-adrenoceptor antagonist doxazosin in both standard formulation and gastrointestinal therapeutic system (GITS) controlled-release formulation is effective for hypertension without having a negative impact on serum lipids. This study was designed to compare the relative efficacy of these two formulations of doxazosin on clinic and ambulatory blood pressure and serum lipids in patients with mild to moderate hypertension. Methods: Hypertensive patients aged 18-70 years (n=335) were evaluated in a multi-center prospective randomized study. Following a 2-week placebo run-in phase, patients were randomized to receive doxazosin 2 or 4 mg, with dose titration, or doxazosin GITS 4 mg, no dose titration, for 9 weeks. Results: Both doxazosin formulations reduced clinic diastolic and systolic blood pressure from baseline (P<0.0001). Doxazosin GITS and doxazosin 4 mg had similar blood pressure-lowering effects. Doxazosin GITS reduced sitting diastolic and systolic blood pressure compared with doxazosin 2 mg (P<0.01 for both). A greater proportion of the doxazosin GITS group reached goal blood pressure (≤140/90 mm Hg) after 9 weeks compared with the doxazosin 2-mg group. All doses of doxazosin reduced 24-h and daytime (7:00 am to 10:00 pm) ambulatory blood pressure from baseline (all P<0.01). Doxazosin GITS significantly reduced nighttime (10:00 pm to 7:00 am) ambulatory blood pressure from baseline. A neutral effect on serum lipids was observed with doxazosin. Conclusions: Doxazosin GITS and doxazosin were effective in reducing clinic and ambulatory blood pressure. The GITS formulation reduced the need for dose titration. Both doxazosin formulations were well tolerated.

Revue / Journal Title

International journal of cardiology   ISSN 0167-5273   CODEN IJCDD5 

Source / Source

2005, vol. 101, n^o1, pp. 97-104 [8 page(s) (article)] (25 ref.)

Langue / Language

Anglais

Editeur / Publisher

Elsevier, Shannon, IRLANDE  (1981) (Revue)

Mots-clés anglais / English Keywords

Cardiovascular disease ; Phlebology ; Cardiology ; Circulatory system ; Lipids ; Serum ; System ; Gastrointestinal ; Ambulatory ; Standards ; Standard ; Comparative study ; Treatment ; Doxazosin ; Arterial pressure ; Blood pressure ; Hypertension ;

Mots-clés français / French Keywords

Appareil circulatoire pathologie ; Phlébologie ; Cardiologie ; Appareil circulatoire ; Lipide ; Sérum ; Système ; Gastrointestinal ; Ambulatoire ; Norme ; Etalon ; Etude comparative ; Traitement ; Doxazosine ; Pression artérielle ; Pression sanguine ; Hypertension artérielle ;

Mots-clés espagnols / Spanish Keywords

Aparato circulatorio patología ; Flebología ; Cardiología ; Aparato circulatorio ; Lípido ; Suero ; Sistema ; Gastrointestinal ; Ambulatorio ; Norma ; Marco ; Estudio comparativo ; Tratamiento ; Doxazosina ; Presión arterial ; Presión sanguínea ; Hipertensión arterial ;

Mots-clés d'auteur / Author Keywords

Ambulatory blood pressure ; Doxazosin ; Gastrointestinal therapeutic system ; Hypertension ; Serum lipids ;

Localisation / Location

INIST-CNRS, Cote INIST : 16457, 35400012547908.0150